About: The interaction of nonstructural protein 9 with retinoblastoma protein benefits the replication of genotype 2 porcine reproductive and respiratory syndrome virus in vitro

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The interaction of nonstructural protein 9 with retinoblastoma protein benefits the replication of genotype 2 porcine reproductive and respiratory syndrome virus in vitro Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The interaction of nonstructural protein 9 with retinoblastoma protein benefits the replication of genotype 2 porcine reproductive and respiratory syndrome virus in vitro
Creator	Zhou, Lei Zhang, Ning Ge, Xinna Guo, Xin Yang, Hanchun Dong, Jianguo
Source	Elsevier; Medline; PMC
abstract	Abstract The nonstructural protein 9 (Nsp9) of porcine reproductive and respiratory syndrome virus (PRRSV) is a RNA-dependent RNA polymerase (RdRp) that plays a vital role in viral replication. This study first demonstrated that the Nsp9 of genotype 2 PRRSV interacted with cellular retinoblastoma protein (pRb), and Nsp9 co-localized with pRb in the cytoplasm of PRRSV-infected MARC-145 cells and pulmonary alveolar macrophages (PAMs). Next, the overexpression of truncated pRb was shown to inhibit the PRRSV replication and silencing the pRb gene could facilitate the PRRSV replication in MARC-145 cells. Finally, the pRb level was confirmed to be down-regulated in PRRSV-infected MARC-145 cells, and Nsp9 was shown to promote the pRb degradation by proteasome pathway. These findings indicate that the interaction of Nsp 9 with pRb benefits the replication of genotype 2 PRRSV in vitro, helping to understand the roles of Nsp9 in the replication and pathogenesis of PRRSV.
has issue date	2014-09-30(xsd:dateTime)
bibo:doi	10.1016/j.virol.2014.07.036
bibo:pmid	25146601
has license	els-covid
sha1sum (hex)	3e7ece0370d329776d55033be6c709a89e6b1cec
schema:url	https://doi.org/10.1016/j.virol.2014.07.036
resource representing a document's title	The interaction of nonstructural protein 9 with retinoblastoma protein benefits the replication of genotype 2 porcine reproductive and respiratory syndrome virus in vitro
has PubMed Central identifier	PMC7112046
has PubMed identifier	25146601
schema:publication	Virology
resource representing a document's body	covid:3e7ece0370d329776d55033be6c709a89e6b1cec#body_text
is schema:about of	named entity 'promote' named entity 'truncated' named entity 'S T' named entity 'FINDINGS' named entity 'DOWN-REGULATED' named entity 'PRB' named entity 'NSP' named entity 'PULMONARY' named entity 'RNA-DEPENDENT RNA POLYMERASE' named entity 'INFECTED' named entity 'PLAYS' named entity 'RETINOBLASTOMA PROTEIN' named entity 'GENOTYPE 2' named entity 'PROTEIN ' named entity 'IS A' named entity 'CONFIRMED' named entity 'VITAL' named entity 'IN VITRO' named entity 'RETINOBLASTOMA PROTEIN' named entity 'DEGRADATION' named entity 'SILENCING' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'VIRAL REPLICATION' named entity 'LEVEL' named entity 'TO INHIBIT' named entity 'REPLICATION' named entity 'TRUNCATED' named entity 'ROLE' named entity 'ROLES' named entity 'DEMONSTRATED' named entity 'PROTEASOME PATHWAY' named entity 'INTERACTION' named entity 'BENEFITS' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'REPLICATION' named entity 'UNDERSTAND' named entity 'STUDY' named entity 'PROTEIN ' named entity 'GENOTYPE 2' named entity 'MARC' named entity 'IN VITRO' named entity 'GENE' named entity 'CELLULAR' named entity 'PROMOTE' named entity 'OVEREXPRESSION' named entity 'ALVEOLAR MACROPHAGES' named entity 'LOCALIZED' named entity '145' named entity 'CELLS' named entity 'INTERACTION' named entity 'THESE' named entity 'PATHOGENESIS' named entity 'CYTOPLASM' named entity 'BENEFITS' named entity 'pulmonary' named entity 'pRb' named entity 'down-regulated' named entity 'alveolar' named entity 'These' named entity 'interaction' named entity 'pRb' named entity 'helping' named entity 'vital' named entity 'proteasome' named entity 'pRb' named entity 'nonstructural protein' named entity 'Genotype' named entity 'pRb' named entity 'alveolar macrophages' named entity 'pRb' named entity 'pRb' named entity 'PAMs' named entity 'nonstructural protein' named entity 'pRb' named entity 'genotype' named entity 'retinoblastoma protein'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software