About: Severe Acute Respiratory Syndrome-Related Coronavirus Is Inhibited by Interferon-α

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Severe Acute Respiratory Syndrome-Related Coronavirus Is Inhibited by Interferon-α Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Severe Acute Respiratory Syndrome-Related Coronavirus Is Inhibited by Interferon-α
Creator	Feldmann, Heinz Li, Yan Jones, Steven Plummer, Frank Aoki, Fred Strong, James Dicaro, Antonino Strö, Ute
Source	Medline; PMC
abstract	Current treatment schemes for severe acute respiratory syndrome (SARS) include broad-spectrum antibiotics, glucocorticoids, and ribavirin. We evaluated the susceptibility of the SARS-related coronavirus (SARS CoV) to ribavirin and interferon (IFN)-α in vitro by use of cytopathic effect, plaque assay, and immunoblot analysis. Ribavirin did not inhibit viral growth at concentrations attainable in human serum. In contrast, IFN-α showed an in vitro inhibitory effect starting at concentrations of 1000 IU/mL. In conclusion, ribavirin alone is unlikely to be beneficial in the prophylaxis or treatment of SARS CoV infections. Clinical trials with IFN-α might be justified to determine a beneficial effect on the outcome of SARS.
has issue date	2004-04-01(xsd:dateTime)
bibo:doi	10.1086/382597
bibo:pmid	15031783
has license	no-cc
sha1sum (hex)	3e8b91d09f699206189e4a70186e2d7b3dda8ea5
schema:url	https://doi.org/10.1086/382597
resource representing a document's title	Severe Acute Respiratory Syndrome-Related Coronavirus Is Inhibited by Interferon-α
has PubMed Central identifier	PMC7109643
has PubMed identifier	15031783
schema:publication	J Infect Dis
resource representing a document's body	covid:3e8b91d09f699206189e4a70186e2d7b3dda8ea5#body_text
is schema:about of	named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'TREATMENT' named entity 'UNLIKELY' named entity 'CORONAVIRUS' named entity 'MIGHT BE' named entity 'PROPHYLAXIS' named entity 'IFN-A' named entity 'DETERMINE' named entity 'OUTCOME' named entity 'CLINICAL TRIALS' named entity 'INTERFERON' named entity 'BENEFICIAL EFFECT' named entity 'SARS' named entity 'BENEFICIAL' named entity 'INHIBITED' named entity 'RELATED' named entity 'INFECTIONS' covid:arg/3e8b91d09f699206189e4a70186e2d7b3dda8ea5 named entity 'IFN-a' named entity 'beneficial' named entity 'beneficial' named entity 'Coronavirus' named entity 'inoculum' named entity 'Toronto' named entity 'Vero E6' named entity 'Viral' named entity 'virus' named entity 'SARS' named entity 'tissue culture' named entity 'SARS' named entity 'Schering-Plough' named entity 'IFN-a' named entity 'Toronto' named entity 'HCV' named entity 'infection' named entity 'agarose' named entity 'SARS CoV' named entity 'serum concentrations' named entity 'virus' named entity 'SARS CoV' named entity 'ribavirin' named entity 'inoculation' named entity 'formalin' named entity 'SARS CoV' named entity 'tissue culture' named entity 'immunoblot' named entity 'IFN-a' named entity 'virus' named entity 'Vero cell' named entity 'DMEM' named entity 'Vero E6' named entity 'Millipore' named entity 'ribavirin' named entity 'SARS CoV' named entity 'cell lysates' named entity 'enhanced chemiluminescence' named entity 'protein expression' named entity 'IFN-a' named entity 'Vero E6' named entity 'Millipore' named entity 'bunyaviruses' named entity 'systemic vasculitis' named entity 'infection' named entity 'SDS-PAGE' named entity 'SARS CoV' named entity 'ribavirin' named entity 'Vero E6' named entity 'Macaca fascicularis' named entity 'Vero E6' named entity 'antiviral treatment' named entity 'DMEM' named entity 'biocontainment' named entity 'infection' named entity 'serum'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software