About: Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome

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About: Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome
Creator	Tang, Jian Feng, · Chen, Xuxin Shuai, Weizheng Meng, · Zhihai, ·
source	PMC
abstract	PURPOSE: Macrophages are highly plastic cells. Under different stimuli, macrophages can be polarized into several different subsets. Two main macrophage subsets have been suggested: classically activated or inflammatory (M1) macrophages and alternatively activated or anti-inflammatory (M2) macrophages. Macrophage polarization is governed by a highly complex set of regulatory networks. Many recent studies have shown that macrophages are key orchestrators in the pathogenesis of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and that regulation of macrophage polarization may improve the prognosis of ALI/ARDS. A further understanding of the mechanisms of macrophage polarization is expected to be helpful in the development of novel therapeutic targets to treat ALI/ARDS. Therefore, we performed a literature review to summarize the regulatory mechanisms of macrophage polarization and its role in the pathogenesis of ALI/ARDS. METHODS: A computer-based online search was performed using the PubMed database and Web of Science database for published articles concerning macrophages, macrophage polarization, and ALI/ARDS. RESULTS: In this review, we discuss the origin, polarization, and polarization regulation of macrophages as well as the role of macrophage polarization in various stages of ARDS. According to the current literature, regulating the polarized state of macrophages might be a potential therapeutic strategy against ALI/ARDS.
has issue date	2020-07-10(xsd:dateTime)
bibo:doi	10.1007/s00011-020-01378-2
bibo:pmid	32647933
has license	no-cc
sha1sum (hex)	3e91ee7d9cad3f0feb2ea60be831a65d42569036
schema:url	https://doi.org/10.1007/s00011-020-01378-2
resource representing a document's title	Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome
has PubMed Central identifier	PMC7347666
has PubMed identifier	32647933
schema:publication	Inflamm Res
resource representing a document's body	covid:3e91ee7d9cad3f0feb2ea60be831a65d42569036#body_text
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