About: Cytokine Profiles Induced by the Novel Swine-Origin Influenza A/H1N1 Virus: Implications for Treatment Strategies

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About: Cytokine Profiles Induced by the Novel Swine-Origin Influenza A/H1N1 Virus: Implications for Treatment Strategies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cytokine Profiles Induced by the Novel Swine-Origin Influenza A/H1N1 Virus: Implications for Treatment Strategies
Creator	Yuen, Kwok-Yung Chan, Kwok-Hung Lau, Susanna Woo, Patrick Lau, Candy Tung, Edward
Source	PMC
abstract	Background. Given the apparent high mortality associated with the novel swine-origin influenza A/H1N1 virus (S-OIV) in Mexico, we aimed to study the cytokine profiles induced by S-OIV and the effect of immunomodulators. Methods. We assayed cytokines and their messenger RNA (mRNA) levels in culture supernatants of human macrophages infected with H5N1, S-OIV California/04/2009 (S-OIV-CA), S-OIV Hong Kong/415742 (S-OIV-HK), or seasonal H1N1 with or without celecoxib and mesalazine. Results. Among the 12 cytokines showing detectable levels, levels of 8 proinflammatory cytokines (interleukin [IL] 2R, IL-6, interferon [IFN] α, macrophage inflammatory protein [MIP] α, MIP-1b, IFN-induced protein 10, regulated on activation, normal T cell expressed and secreted [RANTES], and monocyte chemotactic protein [MCP] 1) were higher in cells infected by H5N1 but similar among cells infected with H1N1, S-OIV-CA, or SOIV- HK. The levels of the other 4 cytokines were similar for H5N1, H1N1, S-OIV-CA and S-OIV-HK. Among the 8 cytokines induced by H5N1, 6 were suppressed by celecoxib and mesalazine. The mRNA levels of tumor necrosis factor a, IFN-γ, IL-6, and MCP-1 induced by H5N1 were higher than the levels of other cytokines at 12 and/or 24 h. Conclusions. No major cytokine storm, as seen in H5N1 infection, is associated with S-OIV infection of cell lines. The mainstay of treatment for uncomplicated S-OIV infections should be antiviral agents without immunomodulators. For individual S-OIV-infected patients with severe primary viral pneumonia, severe sepsis, and multiorgan failure, immunomodulators may be considered as an adjunctive therapy in clinical trials.
has issue date	2010-02-01(xsd:dateTime)
bibo:doi	10.1086/649785
bibo:pmid	20030555
has license	no-cc
sha1sum (hex)	3ecd1dec0230c2c9a6fd423c4124185dd8779786
schema:url	https://doi.org/10.1086/649785
resource representing a document's title	Cytokine Profiles Induced by the Novel Swine-Origin Influenza A/H1N1 Virus: Implications for Treatment Strategies
has PubMed Central identifier	PMC7202468
has PubMed identifier	20030555
schema:publication	J Infect Dis
resource representing a document's body	covid:3ecd1dec0230c2c9a6fd423c4124185dd8779786#body_text
is schema:about of	named entity 'Novel' named entity 'Cytokine' named entity 'Virus' named entity 'macrophages' named entity 'cytokine storm' named entity 'cytokine' named entity 'zanamivir' named entity 'IL-8' named entity 'S-OIV' named entity 'RNA extraction' named entity 'MOIs' named entity 'S-OIV' named entity 'macrophages' named entity 'Cytokine' named entity 'correlation' named entity 'magnesium chloride' named entity 'epithelial cells' named entity 'GE Healthcare' named entity 'mesalazine' named entity 'mmol' named entity 'virulence' named entity 'streptomycin' named entity 'virus' named entity 'mmol' named entity 'RNA extraction' named entity 'swine influenza' named entity 'cytopathic effect' named entity 'A549' named entity 'infection' named entity 'correlation' named entity 'multiorgan failure' named entity 'H5N1' named entity 'cytokine' named entity 'epidemic' named entity 'viral replication' named entity 'mutation' named entity 'TNF' named entity 'MCP-1' named entity 'H1N1 strain' named entity 'Reed-Muench method' named entity 'H5N1' named entity 'macrophages' named entity 'infection' named entity 'H5N1' named entity 'glyceraldehyde 3-phosphate dehydrogenase' named entity 'mice' named entity 'infection' named entity 'clinical features' named entity 'primers' named entity 'virulent' named entity 'ferret' named entity 'H5N1' named entity 'mesalazine' named entity 'mRNA expression' named entity 'virulence' named entity 'mortality rates' named entity 'inoculated' named entity 'animal studies' named entity 'S-OIV' named entity 'MCP-1' named entity 'S-OIV' named entity 'Cytokine' named entity 'MDCK' named entity 'immunomodulators' named entity 'multiorgan failure' named entity 'viral load' named entity 'influenza virus' named entity 'S-OIV' named entity 'S-OIV' named entity 'H1N1' named entity 'macrophages' named entity 'Invitrogen' named entity '2.0' named entity 'IL-5' named entity 'cytokine' named entity 'cytokines'

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