About: Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon
Creator	Julkunen, Ilkka Melén, Krister Westenius, Veera Kakkola, Laura Vapalahti, Olli Jiang, Miao Khan, Hira Lundberg, Rickard
Source	Medline; PMC
abstract	The Zika virus (ZIKV) is a member of the Flaviviridae family and an important human pathogen. Most pathogenic viruses encode proteins that interfere with the activation of host innate immune responses. Like other flaviviruses, ZIKV interferes with the expression of interferon (IFN) genes and inhibits IFN-induced antiviral responses. ZIKV infects through epithelial barriers where IFN-λ1 is an important antiviral molecule. In this study, we analyzed the effects of ZIKV proteins on the activation of IFN-λ1 promoter. All ZIKV proteins were cloned and transiently expressed. ZIKV NS5, but no other ZIKV protein, was able to interfere with the RIG-I signaling pathway. This inhibition took place upstream of interferon regulatory factor 3 (IRF3) resulting in reduced phosphorylation of IRF3 and reduced activation of IFN-λ1 promoter. Furthermore, we showed that ZIKV NS5 interacts with the protein kinase IKKε, which is likely critical to the observed inhibition of phosphorylation of IRF3.
has issue date	2019-11-04(xsd:dateTime)
bibo:doi	10.3390/v11111024
bibo:pmid	31690057
has license	cc-by
sha1sum (hex)	3f2d44465b679efa6237f96e001dcf8a9e9bd6ff
schema:url	https://doi.org/10.3390/v11111024
resource representing a document's title	Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon
has PubMed Central identifier	PMC6893776
has PubMed identifier	31690057
schema:publication	Viruses
resource representing a document's body	covid:3f2d44465b679efa6237f96e001dcf8a9e9bd6ff#body_text
is schema:about of	covid:arg/3f2d44465b679efa6237f96e001dcf8a9e9bd6ff named entity 'ANALYZED' named entity 'EXPRESSION' named entity 'PHOSPHORYLATION' named entity 'PROTEIN' named entity 'UPSTREAM' named entity 'REDUCED' named entity 'LIKELY' named entity 'BUT' named entity 'INTERFERON REGULATORY FACTOR 3' named entity 'MEMBER OF' named entity 'PROMOTER' named entity 'VIRUSES' named entity 'PROTEINS' named entity 'ACTIVATION' named entity 'IKK' named entity 'IRF3' named entity 'STUDY' named entity 'EFFECTS' named entity 'EPITHELIAL' named entity 'CRITICAL' named entity 'FLAVIVIRUSES' named entity 'RIG-I SIGNALING PATHWAY' named entity 'PROTEIN KINASE' named entity 'NS5' named entity 'INTERFERE' named entity 'IFN' named entity 'PATHWAY' named entity 'NON-' named entity 'RESPONSES' named entity 'INTERFERES WITH' named entity 'INHIBITION OF PHOSPHORYLATION' named entity 'INTERFERON ' named entity 'IS A' named entity 'INFECTS' named entity 'GENES' named entity 'STRUCTURAL PROTEIN' named entity 'OBSERVED' named entity 'HUMAN' named entity 'ANTIVIRAL' named entity 'NS5' named entity 'ZIKA VIRUS' named entity 'TOOK PLACE' named entity 'RIG-I' named entity 'PROMOTER ACTIVATION' named entity 'IKK EPSILON' named entity 'ZIKA VIRUS' named entity 'PATHOGEN' named entity 'CLONED' named entity 'MOLECULE' named entity 'WHERE' named entity 'FLAVIVIRIDAE' named entity 'INDUCED' named entity 'IMPORTANT' named entity 'TARGETING' named entity 'INTERFERON LAMBDA 1' named entity 'PROTEIN ' named entity 'EXPRESSED' named entity 'BB1' named entity 'ENCODE' named entity 'LIKE' named entity 'RESULTING IN' named entity 'PATHOGENIC' named entity 'FAMILY' named entity 'INHIBITION' named entity 'HOST' named entity 'IMMUNE RESPONSES' named entity 'ZIKV' named entity 'cloned' named entity 'ZIKV' named entity 'molecule' named entity 'phosphorylation' named entity 'protein' named entity 'innate immune responses'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software