About: A Bat-Derived Putative Cross-Family Recombinant Coronavirus with a Reovirus Gene

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About: A Bat-Derived Putative Cross-Family Recombinant Coronavirus with a Reovirus Gene Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Bat-Derived Putative Cross-Family Recombinant Coronavirus with a Reovirus Gene
Creator	Shi, Yi Wu, Ying Wang, Qihui Yu, Hongjie Song, Jingdong Huang, Canping Ji, Wei Jia, Hao Li, Hong Liu, Di Liu, Guang Liu, Huaxing Lu, Lin Wang, Liang Wen, Honghua Zhao, Honglan Zhao, Yingze Zhou, Yongming Gao, George Holmes, Edward Liu, William Xu, Wj, Liu
Source	Medline; PMC
abstract	The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 has generated enormous interest in the biodiversity, genomics and cross-species transmission potential of coronaviruses, especially those from bats, the second most speciose order of mammals. Herein, we identified a novel coronavirus, provisionally designated Rousettus bat coronavirus GCCDC1 (Ro-BatCoV GCCDC1), in the rectal swab samples of Rousettus leschenaulti bats by using pan-coronavirus RT-PCR and next-generation sequencing. Although the virus is similar to Rousettus bat coronavirus HKU9 (Ro-BatCoV HKU9) in genome characteristics, it is sufficiently distinct to be classified as a new species according to the criteria defined by the International Committee of Taxonomy of Viruses (ICTV). More striking was that Ro-BatCoV GCCDC1 contained a unique gene integrated into the 3’-end of the genome that has no homologs in any known coronavirus, but which sequence and phylogeny analyses indicated most likely originated from the p10 gene of a bat orthoreovirus. Subgenomic mRNA and cellular-level observations demonstrated that the p10 gene is functional and induces the formation of cell syncytia. Therefore, here we report a putative heterologous inter-family recombination event between a single-stranded, positive-sense RNA virus and a double-stranded segmented RNA virus, providing insights into the fundamental mechanisms of viral evolution.
has issue date	2016-09-27(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1005883
bibo:pmid	27676249
has license	cc-by
sha1sum (hex)	3f551bf91d2b52cadac39dbd62e7ae0f51066446
schema:url	https://doi.org/10.1371/journal.ppat.1005883
resource representing a document's title	A Bat-Derived Putative Cross-Family Recombinant Coronavirus with a Reovirus Gene
has PubMed Central identifier	PMC5038965
has PubMed identifier	27676249
schema:publication	PLoS Pathog
resource representing a document's body	covid:3f551bf91d2b52cadac39dbd62e7ae0f51066446#body_text
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