About: Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice

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About: Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice
Creator	Yang, Zi-Feng Wei, Xin Huang, Wan-Yi Khan, Afsar Liu, Ya-Ping Luo, Xiao-Dong Shang, Jian-Hua Wang, Bei Wang, Xin-Hua Wang, Yi-Fen Yuan, Zhi-Wei Zhao, Yun-Li
Source	Elsevier; Medline; PMC
abstract	Abstract Ethnopharmacological relevance Leaf of Alstonia scholaris (L.) R. Br. (Apocynaceae), a wide used ethic-medicine in many Asia and Africa counties, has also been recorded as the common traditional Chinese medicine for treatment of illnesses in respiratory system by Dai people. Aim of the study To provide experimental data of clinical adaption of total indole alkaloids (TA) from leaf of A. scholaris for treating post-infectious cough in phase II clinical trial. Materials and methods To model post-infectious cough, all animals except control group were instilled intra-tracheal with lipopolysaccharide (LPS) (80 μg/50 µL/mouse), followed by subsequent exposure to cigarette smoke (CS) for 30 min per day for a total of 30 days. Mice were orally given TA at dose of 10, 25, 50 mg/kg, and four main alkaloids (Sch: scholaricine, Epi: 19-epischolaricine, Val: vallesamine, Pic: picrinine) once daily. Cellular infiltration was assessed in the broncho-alveolar lavage fluid (BALF). Expression of interleukin-6 (IL-6) and C-reactive protein (CRP) in the serum was determined, the superoxide dismutase (SOD) activity as well as malondialdehyde (MDA) content in the serum and homogenate were examined. Finally, histopathological examination in the lungs was assessed by H. E. staining. Results After administration of TA and four major alkaloids respectively, the symptoms of cough in mice were obviously attenuated. Total white blood cells (WBC) and neutrophils (NEU) amounts in BALF were reduced obviously and the pathological damage of lung was also attenuated. There was also significant reduction in IL-6, CRP, MDA and a marked improvement in SOD. Conclusions The efficacy of indole alkaloids against post-infectious cough (PIC) was shown in the down-regulation of inflammatory cells, cytokines, and the balance of antioxidants. What's more, the pharmacological effects of TA were better than single indole alkaloid, which might be related to the synergic effect of four major alkaloids.
has issue date	2018-05-23(xsd:dateTime)
bibo:doi	10.1016/j.jep.2018.02.040
bibo:pmid	29496577
has license	els-covid
sha1sum (hex)	3fb382f0bd23aaf5f7cf648705119b6f9ad69cfa
schema:url	https://doi.org/10.1016/j.jep.2018.02.040
resource representing a document's title	Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice
has PubMed Central identifier	PMC7126965
has PubMed identifier	29496577
schema:publication	Journal of Ethnopharmacology
resource representing a document's body	covid:3fb382f0bd23aaf5f7cf648705119b6f9ad69cfa#body_text
is schema:about of	named entity 'BALF' named entity 'total' named entity 'Mice' named entity 'treating' named entity 'indole' named entity 'attenuated' named entity 'indole' named entity 'Materials' named entity 'LPS' named entity 'malondialdehyde' named entity 'INDOLE ALKALOIDS' named entity 'PICRININE' named entity 'SYMPTOMS' named entity 'COUNTIES' named entity 'SUPEROXIDE DISMUTASE' named entity 'EFFECT' named entity 'BRONCHO-ALVEOLAR LAVAGE' named entity 'ATTENUATED' named entity 'ETHIC' named entity 'ALKALOIDS' named entity 'CYTOKINES' named entity 'SINGLE' named entity 'MARKED' named entity 'PHASE II CLINICAL TRIAL' named entity 'USED' named entity 'ANTIOXIDANTS' named entity 'PROTEIN ' named entity 'REDUCED' named entity 'RESULTS' named entity 'MIGHT BE' named entity 'TREATMENT' named entity 'RELATED' named entity 'HOMOGENATE' named entity 'DAYS' named entity 'MODEL' named entity 'EXPERIMENTAL DATA' named entity 'WHAT' named entity 'CONTENT' named entity 'INDOLE ALKALOID' named entity 'METHODS' named entity 'POST' named entity 'MATERIALS' named entity 'CLINICAL' named entity 'AIM' named entity 'BALANCE' named entity 'PER DAY' named entity 'TO PROVIDE' named entity 'GIVEN' named entity 'INTERLEUKIN-6 ' named entity 'IL-6' named entity 'CRP' named entity 'INTRATRACHEAL' named entity 'INFLAMMATORY CELLS' named entity 'C-REACTIVE PROTEIN' named entity 'DAMAGE' named entity 'TREATING' named entity 'POST' named entity 'ALSTONIA SCHOLARIS' named entity 'IMPROVEMENT' named entity 'WHITE BLOOD CELLS' named entity 'ADMINISTRATION' named entity 'CELLULAR INFILTRATION' named entity 'HISTOPATHOLOGICAL' named entity 'CONTROL GROUP' named entity 'ILLNESSES' named entity 'COUGH' named entity 'SUBSEQUENT' named entity 'ASIA' named entity 'MG%' named entity 'PHARMACOLOGICAL'

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