About: Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons

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About: Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons
Creator	Slevogt, Hortense Klaile, Esther Bals, Robert Dienemann, Hendrik Grünewald, Christiane Heinrich, Annina Scheffrahn, Inka Heyl, Kerstin Klassert, Tilman Müller, Mario Singer, Bernhard
Source	Medline; PMC
abstract	BACKGROUND: The carcinoembryonic antigen (CEA)-related cell adhesion molecules CEACAM1 (BGP, CD66a), CEACAM5 (CEA, CD66e) and CEACAM6 (NCA, CD66c) are expressed in human lung. They play a role in innate and adaptive immunity and are targets for various bacterial and viral adhesins. Two pathogens that colonize the normally sterile lower respiratory tract in patients with chronic obstructive pulmonary disease (COPD) are non-typable Haemophilus influenzae (NTHI) and Moraxella catarrhalis. Both pathogens bind to CEACAMs and elicit a variety of cellular reactions, including bacterial internalization, cell adhesion and apoptosis. METHODS: To analyze the (co-) expression of CEACAM1, CEACAM5 and CEACAM6 in different lung tissues with respect to COPD, smoking status and granulocyte infiltration, immunohistochemically stained paraffin sections of 19 donors were studied. To address short-term effects of cigarette smoke and acute inflammation, transcriptional regulation of CEACAM5, CEACAM6 and different CEACAM1 isoforms by cigarette smoke extract, interferons, Toll-like receptor agonists, and bacteria was tested in normal human bronchial epithelial (NHBE) cells by quantitative PCR. Corresponding CEACAM protein levels were determined by flow cytometry. RESULTS: Immunohistochemical analysis of lung sections showed the most frequent and intense staining for CEACAM1, CEACAM5 and CEACAM6 in bronchial and alveolar epithelium, but revealed no significant differences in connection with COPD, smoking status and granulocyte infiltration. In NHBE cells, mRNA expression of CEACAM1 isoforms CEACAM1-4L, CEACAM1-4S, CEACAM1-3L and CEACAM1-3S were up-regulated by interferons alpha, beta and gamma, as well as the TLR3 agonist polyinosinic:polycytidylic acid (poly I:C). Interferon-gamma also increased CEACAM5 expression. These results were confirmed on protein level by FACS analysis. Importantly, also NTHI and M. catarrhalis increased CEACAM1 mRNA levels. This effect was independent of the ability to bind to CEACAM1. The expression of CEACAM6 was not affected by any treatment or bacterial infection. CONCLUSIONS: While we did not find a direct correlation between CEACAM1 expression and COPD, the COPD-associated bacteria NTHi and M. catarrhalis were able to increase the expression of their own receptor on host cells. Further, the data suggest a role for CEACAM1 and CEACAM5 in the phenomenon of increased host susceptibility to bacterial infection upon viral challenge in the human respiratory tract.
has issue date	2013-08-14(xsd:dateTime)
bibo:doi	10.1186/1465-9921-14-85
bibo:pmid	23941132
has license	cc-by
sha1sum (hex)	3fb8269503a524e2257482ce479a05abd732ddfe
schema:url	https://doi.org/10.1186/1465-9921-14-85
resource representing a document's title	Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons
has PubMed Central identifier	PMC3765474
has PubMed identifier	23941132
schema:publication	Respir Res
resource representing a document's body	covid:3fb8269503a524e2257482ce479a05abd732ddfe#body_text
is schema:about of	named entity 'CARCINOEMBRYONIC ANTIGEN' named entity 'CEA' named entity 'CEA' named entity 'HUMAN LUNG' named entity 'NON-' named entity 'ELICIT' named entity 'CD66A' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'TARGETS' named entity 'MORAXELLA CATARRHALIS' named entity 'VARIOUS' named entity 'HAEMOPHILUS INFLUENZAE' named entity 'EXPRESSED' named entity 'EPITHELIAL CELLS' named entity 'LOWER RESPIRATORY TRACT' named entity 'PLAY' named entity 'CEACAM6' named entity 'ADAPTIVE IMMUNITY' named entity '2C CELL' named entity 'CELLULAR' named entity 'TLR3' named entity 'BRONCHIAL' named entity 'MODULATED' named entity 'PATIENTS' named entity 'INTERNALIZATION' named entity 'TYPE I' named entity 'CELL ADHESION MOLECULES' named entity 'RELATED' named entity 'EXPRESSION' named entity 'MORAXELLA CATARRHALIS' named entity 'ROLE' named entity 'CEACAM5' named entity 'RELATED' named entity 'VIRAL' named entity 'PATHOGENS' named entity 'CARCINOEMBRYONIC ANTIGEN' named entity 'REACTIONS' named entity 'CD66E' named entity 'CELL ADHESION MOLECULES' named entity 'CD66C' named entity 'APOPTOSIS' named entity 'NON-' named entity 'INCLUDING' named entity 'EXPRESSED' named entity 'BIND' named entity 'STERILE' named entity 'THEIR' named entity 'BACKGROUND' named entity 'HUMAN LUNG' named entity 'VARIETY' named entity 'CELL ADHESION' named entity 'ADHESINS' named entity 'CEACAM1' named entity 'INTERFERONS' named entity 'BACTERIAL' named entity 'HAEMOPHILUS INFLUENZAE' covid:arg/3fb8269503a524e2257482ce479a05abd732ddfe named entity 'respiratory tract' named entity 'adaptive' named entity 'human interferon gamma' named entity 'lung resection' named entity 'CEACAM1' named entity 'co-expression' named entity 'human pathogens' named entity 'housekeeping genes' named entity 'bacterial pathogens' named entity 'acute inflammation' named entity 'COPD' named entity 'poly I:C' named entity 'granulocyte' named entity 'wild type'

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