About: DNA Vaccine Encoding Middle East Respiratory Syndrome Coronavirus S1 Protein Induces Protective Immune Responses in Mice

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: DNA Vaccine Encoding Middle East Respiratory Syndrome Coronavirus S1 Protein Induces Protective Immune Responses in Mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	DNA Vaccine Encoding Middle East Respiratory Syndrome Coronavirus S1 Protein Induces Protective Immune Responses in Mice
Creator	Xia, Xianzhu Yang, Songtao Wang, Chong Zhao, Jincun Perlman, Stanley Chi, Hang Gai, Weiwei Wang, Hualei Zheng, Xuexing Wang, Xiwen
Source	Elsevier; Medline; PMC
abstract	The Middle East respiratory syndrome coronavirus (MERS-CoV), is an emerging pathogen that continues to cause outbreaks in the Arabian peninsula and in travelers from this region, raising the concern that a global pandemic could occur. Here, we show that a DNA vaccine encoding the first 725 amino acids (S1) of MERS-CoV spike (S) protein induces antigen-specific humoral and cellular immune responses in mice. With three immunizations, high titers of neutralizing antibodies (up to 1: 10(4)) were generated without adjuvant. DNA vaccination with the MERS-CoV S1 gene markedly increased the frequencies of antigen-specific CD4(+) and CD8(+) T cells secreting IFN-γ and other cytokines. Both pcDNA3.1-S1 DNA vaccine immunization and passive transfer of immune serum from pcDNA3.1-S1 vaccinated mice protected Ad5-hDPP4-transduced mice from MERS-CoV challenge. These results demonstrate that a DNA vaccine encoding MERS-CoV S1 protein induces strong protective immune responses against MERS-CoV infection.
has issue date	2017-04-01(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2017.02.063
bibo:pmid	28314561
has license	bronze-oa
sha1sum (hex)	3fdc7c236b854cbc809e10b2cc1628102f5c7e6c
schema:url	https://doi.org/10.1016/j.vaccine.2017.02.063
resource representing a document's title	DNA Vaccine Encoding Middle East Respiratory Syndrome Coronavirus S1 Protein Induces Protective Immune Responses in Mice
has PubMed Central identifier	PMC5411280
has PubMed identifier	28314561
schema:publication	Vaccine
resource representing a document's body	covid:3fdc7c236b854cbc809e10b2cc1628102f5c7e6c#body_text
is schema:about of	named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'The Middle' named entity 'mice' named entity 'MERS-CoV' named entity 'ENCODING' named entity 'FREQUENCIES' named entity 'DNA VACCINE' named entity 'MARKEDLY' named entity 'INFECTION' named entity 'RESULTS' named entity 'EMERGING PATHOGEN' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'PROTEIN ' named entity 'IMMUNE RESPONSES' named entity 'AD5' named entity 'PROTEIN ' named entity 'SECRETING' named entity 'CHALLENGE' named entity 'CONCERN' named entity 'MICE' named entity 'DNA VACCINE' named entity 'IMMUNIZATIONS' named entity 'CELLULAR' named entity 'CYTOKINES' named entity 'IMMUNE SERUM' named entity 'TRAVELERS' named entity 'AMINO ACIDS' named entity 'ARABIAN PENINSULA' named entity 'VACCINATED' named entity 'IFN' named entity 'INCREASED' named entity 'THESE' named entity 'CAUSE' named entity 'A DNA' named entity 'SPECIFIC' named entity '725' named entity 'HIGH' named entity 'ADJUVANT' named entity 'MICE' named entity 'GENERATED' named entity 'VACCINE IMMUNIZATION' named entity 'DNA VACCINATION' named entity 'NEUTRALIZING ANTIBODIES' named entity 'CD8' named entity 'OCCUR' named entity 'T CELLS' named entity 'S1 GENE' named entity 'SPIKE' named entity 'REGION' named entity 'PASSIVE' named entity 'TRANSFER' named entity 'OUTBREAKS' named entity 'STRONG' named entity 'ENCODING' named entity 'HERE' named entity 'CD4' named entity 'ANTIGEN' named entity 'GLOBAL' named entity '28S' named entity 'HDPP4' named entity 'IMMUNE RESPONSES' named entity 'PANDEMIC' covid:arg/3fdc7c236b854cbc809e10b2cc1628102f5c7e6c named entity 'induces' named entity 'MERS-CoV' named entity 'cytokines' named entity 'encoding' named entity 'protein' named entity 'MERS-CoV' named entity 'generated' named entity 'Arabian peninsula' named entity 'spike (S) protein'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software