About: Viruses as Quasispecies: Biological Implications

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viruses as Quasispecies: Biological Implications
Creator	Arias, · Domingo, E García-Arriaza, J Grande-Pérez, · Martín, V Perales, ·
Source	Medline; PMC
abstract	During viral infections, the complex and dynamic distributions of variants, termed viral quasispecies, play a key role in the adaptability of viruses to changing environments and the fate of the population as a whole. Mutant spectra are continuously and avoidably generated during RNA genome replication, and they are not just a by-product of error-prone replication, devoid of biological relevance. On the contrary, current evidence indicates that mutant spectra contribute to viral pathogenesis, can modulate the expression of phenotypic traits by subpopulations of viruses, can include memory genomes that reflect the past evolutionary history of the viral lineage, and, furthermore, can participate in viral extinction through lethal mutagenesis. Also, mutant spectra are the target on which selection and random drift act to shape the long-term evolution of viruses. The biological relevance of mutant spectra is the central topic of this chapter.
has issue date	2006-01-01(xsd:dateTime)
bibo:doi	10.1007/3-540-26397-7_3
bibo:pmid	16568896
has license	no-cc
sha1sum (hex)	3fec1d8c1c53fcf800e5efb362ad214e901196fd
schema:url	https://doi.org/10.1007/3-540-26397-7_3
resource representing a document's title	Viruses as Quasispecies: Biological Implications
has PubMed Central identifier	PMC7120838
has PubMed identifier	16568896
schema:publication	Quasispecies: Concept and Implications for Virology
resource representing a document's body	covid:3fec1d8c1c53fcf800e5efb362ad214e901196fd#body_text
is schema:about of	named entity 'VIRUSES' named entity 'QUASISPECIES' named entity 'BIOLOGICAL' named entity 'Biological' named entity 'Viruses' named entity 'noninfectious' named entity 'mammalian species' named entity 'long-term' named entity 'genomes' named entity 'phenotypic change' named entity 'genome' named entity 'Sevilla' named entity 'evolution' named entity 'population structure' named entity 'CLUSTAL' named entity 'genetic bottlenecks' named entity 'phosphorylated' named entity 'experimental evidence' named entity 'resistant to antibiotics' named entity 'viral quasispecies' named entity 'evolution' named entity 'Viral quasispecies' named entity 'vaccine' named entity 'heritable' named entity 'virus strain' named entity 'selective constraint' named entity 'protein synthesis' named entity 'protein' named entity 'self-organization' named entity 'virologists' named entity 'cell culture' named entity 'genetic basis' named entity 'organism' named entity 'RNA viruses' named entity 'genetic variation' named entity 'genomes' named entity 'population size' named entity 'viral genome' named entity 'consensus sequence' named entity 'virus genome' named entity 'infectious diseases' named entity 'infection' named entity 'mutational pressure' named entity 'genomic sequences' named entity 'holistic view' named entity 'HIV-1' named entity 'DNA viruses' named entity 'HIV infections' named entity 'quasispecies' named entity 'positive and negative selection' named entity 'viral particles' named entity 'quasispecies' named entity 'probability' named entity 'viral replication' named entity 'genomic sequences' named entity 'life cycle' named entity 'cell cultures' named entity 'Viral genomes' named entity 'FMDV' named entity 'wild-type' named entity 'genomes' named entity 'mutagenic activity' named entity 'RNA genomes' named entity 'chemical mutagens' named entity 'viral infections' named entity 'Eigen' named entity 'sequence space' named entity 'genomes' named entity 'genomes' named entity 'dominant-negative' named entity 'Cell culture' named entity 'mutational pressure' named entity 'Klosters' named entity 'life cycle' named entity 'FMDV' named entity 'viral protein'

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