About: 3D-quantitative structure–activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase

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About: 3D-quantitative structure–activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	3D-quantitative structure–activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase
Creator	Li, Yun Fang Zhao, · Lai, Yanni Liao, Shanghui Liu, Ni Xu, Peiping Yan, Yiwen Ye, Yi
Source	PMC
abstract	Curcumin derivatives have been shown to inhibit replication of human influenza A viruses (IAVs). However, it is not clear whether curcumin and its derivatives can inhibit neuraminidase (NA) of influenza virus. In this study, a meaningful 3D quantitative structure–activity relationship model (comparative molecular field analysis R(2) = 0.997, q(2) = 0.527, s = 0.064, F = 282.663) was built to understand the chemical–biological interactions between their activities and neuraminidase. Molecular docking was used to predict binding models between curcumin derivatives and neuraminidase. Real-time polymerase chain reactions showed that the five active curcumin derivatives might have direct effects on viral particle infectivity in H1N1-infected lung epithelial (MDCK) cells. Neuraminidase activation assay showed that five active curcumin derivatives decreased H1N1-induced neuraminidase activation in MDCK cells. Indirect immunofluorescence assay indicated that two active curcumin derivatives (tetramethylcurcumin and curcumin) down-regulated the nucleoprotein expression. Curcumin inhibited IAV in vivo. The therapeutic mechanism of curcumin in the treatment of influenza viral pneumonia is related to improving the immune function of infected mice and regulating secretion of tumor necrosis-α, interleukin-6, and interferon-γ. These results indicate that curcumin derivatives inhibit IAV by blocking neuraminidase in the cellular model and curcumin also has anti-IAV activity in the animal model.
has issue date	2020-04-04(xsd:dateTime)
bibo:doi	10.1007/s12272-020-01230-5
bibo:pmid	32248350
has license	no-cc
sha1sum (hex)	4017196ee80a233f45df9623bdbd469d81ce0106
schema:url	https://doi.org/10.1007/s12272-020-01230-5
resource representing a document's title	3D-quantitative structure–activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase
has PubMed Central identifier	PMC7125423
has PubMed identifier	32248350
schema:publication	Arch Pharm Res
resource representing a document's body	covid:4017196ee80a233f45df9623bdbd469d81ce0106#body_text
is schema:about of	named entity 'TNF-α' named entity 'Suzuki' named entity 'conformation' named entity 'antibodies' named entity 'Frickenhausen' named entity 'curcumin' named entity 'BMG' named entity 'curcumin' named entity 'neuraminidase' named entity 'carboxylate' named entity 'Dulbecco's modified Eagle's medium' named entity 'CoMFA' named entity 'molecular docking' named entity 'ligand' named entity 'viral shedding' named entity 'IFN-γ' named entity 'carboxylate' named entity 'curcumin' named entity 'MDCK' named entity 'viruses' named entity '4.20' named entity 'correlation coefficient' named entity 'carboxylate' named entity 'carboxylate' named entity 'FBS' named entity 'IAV' named entity 'oseltamivir' named entity 'CoMFA' named entity 'infection' named entity 'neuraminidase' named entity 'oseltamivir' named entity 'lung' named entity 'quantitative structure-activity relationship' named entity 'viral RNA' named entity 'anesthesia' named entity 'bisdemethoxycurcumin' named entity 'antiviral' named entity 'IFN-γ' named entity 'curcumin' named entity 'curcumin' named entity 'CoMFA' named entity 'orthomyxoviridae' named entity 'lung' named entity 'curcumin' named entity 'cell proliferation' named entity 'gavage' named entity 'QSAR' named entity 'viral pneumonia' named entity '3D-QSAR' named entity 'oseltamivir' named entity 'regression analysis' named entity 'curcumin' named entity 'Assay' named entity 'infection' named entity 'cross-validation' named entity 'H1N1' named entity 'curcumin' named entity 'polymerase chain reactions' named entity 'control group' named entity 'hemagglutinin' named entity 'force fields' named entity 'curcumin' named entity 'Curcumin' named entity 'intraperitoneal injection' named entity 'neuraminidase' named entity 'double bond' named entity 'necrosis' named entity 'dimethylcurcumin' named entity 'steric' named entity 'neuraminidase' named entity '1.2' named entity 'infection' named entity 'IAV' named entity 'IAV'

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