About: Human bocavirus in children: Mono-detection, high viral load and viraemia are associated with respiratory tract infection

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About: Human bocavirus in children: Mono-detection, high viral load and viraemia are associated with respiratory tract infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Human bocavirus in children: Mono-detection, high viral load and viraemia are associated with respiratory tract infection
Creator	Christensen, Andreas Døllner, Henrik Krokstad, Sidsel Nordbø, Svein Gro, Anne Rognlien, Wesenberg
source	Elsevier; Medline; PMC
abstract	BACKGROUND AND OBJECTIVES: Human bocavirus 1 (HBoV1) has recently been detected in children with respiratory tract infections (RTI). In order to study whether HBoV1 can cause RTI, we investigated its presence in children with upper RTI (URTI), lower RTI (LRTI) and a control group of children without RTI. STUDY DESIGN: Nasopharyngeal aspirates (NPA) and blood samples were collected from children admitted to hospital with RTI from 6 June 2007 to 28 February 2009 (n = 1154), and from children admitted for elective surgery who had no RTI (n = 162). Using polymerase chain reaction (PCR), the NPAs were examined for 17 infectious agents including HBoV1. Blood samples were tested with HBoV1-PCR only. RESULTS: HBoV1 was detected in NPAs from 10% of patients and 17% of controls. Adjusted for age, gender and the presence of other viruses, HBoV1 was not associated with RTI. In the HBoV1-positive NPAs, at least one other virus was detected in 75% and the virus appeared alone in 25%. Adjusted for age and gender, the detection of HBoV1 as the sole virus was associated with RTI, but not with LRTI. Viraemia was found only in children with RTI. The study showed that it was associated with RTI and LRTI. A high HBoV1-load was associated with LRTI, but not with RTI. No interactions between HBoV1 and other infectious agents were found. CONCLUSIONS: Our data support the hypothesis that HBoV1 causes RTI in children, because detection of HBoV1 alone, viraemia and high viral load are associated with RTI and/or LRTI in this age group. However, HBoV1 is common in healthy children.
has issue date	2010-09-15(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2010.07.016
bibo:pmid	20833582
has license	no-cc
sha1sum (hex)	40187ae285adc4890e73a767bf78d18f570bc95c
schema:url	https://doi.org/10.1016/j.jcv.2010.07.016
resource representing a document's title	Human bocavirus in children: Mono-detection, high viral load and viraemia are associated with respiratory tract infection
has PubMed Central identifier	PMC7108378
has PubMed identifier	20833582
schema:publication	J Clin Virol
resource representing a document's body	covid:40187ae285adc4890e73a767bf78d18f570bc95c#body_text
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