About: Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5

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About: Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5
Creator	Ly, Hinh Brisse, Morgan Gack, Michaela De Nardo, Dominic Pandey, Surya
source	Medline; PMC
abstract	RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen-associated molecular patterns (PAMPs) in the form of viral double-stranded RNA (dsRNA) motifs to induce expression of type 1 interferons (IFN1) (IFNα and IFNβ) and other pro-inflammatory cytokines during the early stage of viral infection. While RIG-I and MDA5 share many genetic, structural and functional similarities, there is increasing evidence that they can have significantly different strategies to recognize different pathogens, PAMPs, and in different host species. This review article discusses the similarities and differences between RIG-I and MDA5 from multiple perspectives, including their structures, evolution and functional relationships with other cellular proteins, their differential mechanisms of distinguishing between host and viral dsRNAs and interactions with host and viral protein factors, and their immunogenic signaling. A comprehensive comparative analysis can help inform future studies of RIG-I and MDA5 in order to fully understand their functions in order to optimize potential therapeutic approaches targeting them.
has issue date	2019-07-17(xsd:dateTime)
bibo:doi	10.3389/fimmu.2019.01586
bibo:pmid	31379819
has license	cc-by
sha1sum (hex)	401ebad7d8d7416f0bf26c8192eb57bfb61f378b
schema:url	https://doi.org/10.3389/fimmu.2019.01586
resource representing a document's title	Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5
has PubMed Central identifier	PMC6652118
has PubMed identifier	31379819
schema:publication	Front Immunol
resource representing a document's body	covid:401ebad7d8d7416f0bf26c8192eb57bfb61f378b#body_text
is schema:about of	named entity 'RECEPTORS' named entity 'viral' named entity 'motifs' named entity 'protein' named entity 'MDA5' named entity 'RIG-I' named entity 'RIG-I' named entity 'induce expression' named entity 'RELATIONSHIPS' named entity 'HOST' named entity 'VIRAL PROTEIN' named entity 'KEY' named entity 'RECEPTORS' named entity 'SENSORS' named entity 'GENETIC' named entity 'KNOWN' named entity 'ORDER' named entity 'PATHOGENS' named entity 'PAMPS' named entity 'COMPREHENSIVE' named entity 'THERAPEUTIC' named entity 'COMPARATIVE ANALYSIS' named entity 'DIFFERENTIATION' named entity 'GENE' named entity 'MECHANISMS' named entity 'DOUBLE-STRANDED RNA' named entity 'STUDIES' named entity 'STRUCTURE' named entity 'LIKE' named entity 'EVOLUTION' named entity 'STRATEGIES' named entity 'INTERFERONS' named entity 'VIRAL INFECTION' named entity 'EXPRESSION' named entity 'SIGNALING' named entity 'MOLECULAR' named entity 'FUNCTION ANALYSIS' named entity 'MDA5' named entity 'RIG-I' named entity 'INDUCE' named entity 'ACID' named entity 'ARTICLE' named entity 'TARGETING' named entity 'IMMUNOGENIC' named entity 'DIFFERENTIAL' named entity 'FUNCTIONAL' named entity 'CELLULAR' named entity 'FULLY' named entity 'FUNCTIONS' named entity 'POTENTIAL' named entity 'PROTEIN ' named entity 'INCREASING' named entity 'INFLAMMATORY' named entity 'MOTIFS' named entity 'DISTINGUISHING' named entity 'TYPE 1' named entity 'INFORM' named entity 'PRO-' named entity 'LIKE' named entity 'STRUCTURES' named entity 'FUTURE' named entity 'PATHOGEN' named entity 'CYTOKINES' named entity 'IFN' named entity 'RIG-I' named entity 'APPROACHES' named entity 'MDA5' named entity 'FORM' named entity 'UNDERSTAND' named entity 'MULTIPLE' named entity 'THEIR' named entity 'ASSOCIATED' named entity 'VIRAL' named entity 'REVIEW' named entity 'HAVE' named entity 'PATTERNS' named entity 'DIFFERENT'

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