About: Urinary YKL-40 as a Candidate Biomarker for Febrile Urinary Tract Infection in Young Children

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Urinary YKL-40 as a Candidate Biomarker for Febrile Urinary Tract Infection in Young Children
Creator	Lee, Juyoung Suh, Jin-Soon Kim, Hyun Cho, Kyoung Bin, Joong Chung, Mi
Source	Medline; PMC
abstract	BACKGROUND: Given that YKL-40 is a known marker of inflammation, we sought to determine its association with urinary tract infection (UTI) in febrile children. METHODS: In total, 44 children aged 0 to 24 months with febrile UTI and 35 age- and sex-matched controls with fever from other causes were enrolled in the study. ELISA was performed to determine the level of YKL-40 in urine collected from each child. RESULTS: The ratio of urinary YKL-40 to creatinine (Cr) was higher in the children with a UTI than in the controls (P<0.001). The area under the ROC curve for detecting UTI was 0.88 for the urinary YKL-40/Cr ratio, 0.86 for pyuria, and 0.71 for positive nitrite on urinalysis. We applied a cut-off value of 125.23 pg/mg to urinary YKL-40/Cr for detecting UTI. Eight of nine children in the control group with pyuria had urinary YKL-40/Cr levels lower than 125.23 pg/mg, and the one child in the UTI group without pyuria or positive nitrite had a urinary YKL-40/Cr level greater than 125.23 pg/mg. CONCLUSIONS: Determining the levels of urinary YKL-40/Cr may help identify true cases of UTI in febrile young children, especially when they have pyuria but not nitrite, or have neither pyuria nor nitrite in the urine.
has issue date	2017-10-23(xsd:dateTime)
bibo:doi	10.3343/alm.2018.38.1.39
bibo:pmid	29071817
has license	cc-by-nc
sha1sum (hex)	404f219ad630336f512bb52d5e6b357adf10e130
schema:url	https://doi.org/10.3343/alm.2018.38.1.39
resource representing a document's title	Urinary YKL-40 as a Candidate Biomarker for Febrile Urinary Tract Infection in Young Children
has PubMed Central identifier	PMC5700145
has PubMed identifier	29071817
schema:publication	Ann Lab Med
resource representing a document's body	covid:404f219ad630336f512bb52d5e6b357adf10e130#body_text
is schema:about of	named entity 'ITS' named entity 'ASSOCIATION' named entity 'KNOWN' named entity 'MARKER' named entity 'DETERMINE' named entity 'URINARY TRACT INFECTION' named entity 'CHILDREN' named entity 'YKL-40' named entity 'FEBRILE URINARY TRACT INFECTION' named entity 'BIOMARKER' named entity 'BACKGROUND' named entity 'GIVEN' named entity 'INFLAMMATION' named entity 'YKL-40' named entity 'CANDIDATE' named entity 'FEBRILE' named entity 'URINARY' named entity 'YOUNG CHILDREN' named entity 'IS A' covid:arg/404f219ad630336f512bb52d5e6b357adf10e130 named entity 'excretion' named entity 'urinalysis' named entity 'NF-κB' named entity 'inflammation' named entity 'UTI' named entity 'non-parametric distributions' named entity 'YKL-40' named entity 'fever' named entity 'protein' named entity 'UTIs' named entity 'YKL-40' named entity 'murine' named entity 'control group' named entity 'pyuria' named entity 'lamina propria' named entity 'parainfluenza' named entity 'hematuria' named entity 'YKL-40' named entity 'cardiovascular' named entity 'MAPK' named entity 'assay' named entity 'pyuria' named entity 'pyuria' named entity 'Escherichia coli' named entity 'YKL-40' named entity 'febrile' named entity 'inflammation' named entity 'ROC curves' named entity 'DMSA' named entity 'YKL-40' named entity 'YKL-40' named entity 'pyuria' named entity 'Catholic University of Korea' named entity 'adenovirus infection' named entity 'run the risk' named entity 'YKL-40' named entity 'standard curve' named entity 'UTI' named entity 'graft' named entity 'antibiotics' named entity 'extracellular matrix' named entity 'UTI' named entity 'UTI' named entity 'cut-off' named entity 'inflammatory markers' named entity 'UTI' named entity 'inflammation' named entity 'kidney injury' named entity 'centrifuged' named entity 'imaging studies' named entity 'UTI' named entity 'inflammation' named entity 'ESR' named entity 'pyuria' named entity 'UTI' named entity 'fever'

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