About: Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice
Creator	Bahgat, M Bertram, S Hatesuer, B Mehnert, N Nelson, P
Source	Medline; PMC
abstract	Annual influenza epidemics and occasional pandemics pose a severe threat to human health. Host cell factors required for viral spread but not for cellular survival are attractive targets for novel approaches to antiviral intervention. The cleavage activation of the influenza virus hemagglutinin (HA) by host cell proteases is essential for viral infectivity. However, it is unknown which proteases activate influenza viruses in mammals. Several candidates have been identified in cell culture studies, leading to the concept that influenza viruses can employ multiple enzymes to ensure their cleavage activation in the host. Here, we show that deletion of a single HA-activating protease gene, Tmprss2, in mice inhibits spread of mono-basic H1N1 influenza viruses, including the pandemic 2009 swine influenza virus. Lung pathology was strongly reduced and mutant mice were protected from weight loss, death and impairment of lung function. Also, after infection with mono-basic H3N2 influenza A virus body weight loss and survival was less severe in Tmprss2 mutant compared to wild type mice. As expected, Tmprss2-deficient mice were not protected from viral spread and pathology after infection with multi-basic H7N7 influenza A virus. In conclusion, these results identify TMPRSS2 as a host cell factor essential for viral spread and pathogenesis of mono-basic H1N1 and H3N2 influenza A viruses.
has issue date	2013-12-05(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1003774
bibo:pmid	24348248
has license	cc-by
sha1sum (hex)	4070000cd4a0880ff387df1d1a42f5f45f34e015
schema:url	https://doi.org/10.1371/journal.ppat.1003774
resource representing a document's title	Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice
has PubMed Central identifier	PMC3857797
has PubMed identifier	24348248
schema:publication	PLoS Pathog
resource representing a document's body	covid:4070000cd4a0880ff387df1d1a42f5f45f34e015#body_text
is schema:about of	named entity 'lung function' named entity 'pathology' named entity 'concept' named entity 'wild type' named entity 'Host' named entity 'influenza' covid:arg/4070000cd4a0880ff387df1d1a42f5f45f34e015 named entity 'BUT' named entity 'INFLUENZA VIRUSES' named entity 'PATHOGENESIS' named entity 'THREAT' named entity 'H3N2 INFLUENZA' named entity 'BODY WEIGHT LOSS' named entity 'AS EXPECTED' named entity 'BASIC' named entity 'EMPLOY' named entity 'HUMAN HEALTH' named entity 'MONO' named entity 'MULTI' named entity 'DELETION' named entity 'HERE' named entity 'PROTEASES' named entity 'UNKNOWN' named entity 'IDENTIFY' named entity 'MAMMALS' named entity 'REDUCED' named entity 'WILD TYPE' named entity 'HOST CELL FACTOR' named entity 'CELLULAR' named entity 'HAVE' named entity 'NOVEL' named entity 'INFECTIVITY' named entity 'LUNG' named entity 'INCLUDING' named entity 'DEFICIENT' named entity 'LEADING' named entity 'APPROACHES' named entity 'ACTIVATING' named entity 'HEMAGGLUTININ' named entity 'CLEAVAGE' named entity 'CELL CULTURE' named entity 'ACTIVATE' named entity 'H1N1 INFLUENZA' named entity 'CONCLUSION' named entity 'SURVIVAL' named entity 'ENZYMES' named entity 'ESSENTIAL' named entity 'REQUIRED' named entity 'ACTIVATION' named entity 'INFECTION' named entity 'RESULTS' named entity 'SINGLE' named entity 'THEIR' named entity 'IMPAIRMENT' named entity 'INFLUENZA' named entity 'DEATH' named entity 'MICE' named entity 'SEVERE' named entity 'ATTRACTIVE' named entity 'H1N1' named entity 'INFLUENZA H1N1' named entity 'VIRUS' named entity 'STUDIES' named entity 'IDENTIFIED' named entity 'PROTEASE GENE' named entity 'SPREAD' named entity 'VIRAL' named entity 'SWINE INFLUENZA VIRUS' named entity 'COMPARED' named entity 'HOST CELL' named entity 'MULTIPLE' named entity 'POSE' named entity 'INFLUENZA A' named entity 'ANNUAL' named entity 'PANDEMICS' named entity 'ESSENTIAL' named entity 'LUNG FUNCTION'

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