About: Understanding cellular interactions with nanomaterials: towards a rational design of medical nanodevices

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Understanding cellular interactions with nanomaterials: towards a rational design of medical nanodevices
Creator	Castro-Lugo, Andrés Palomares, Laura Ramírez, Octavio Villanueva-Flores, Francisca
Source	PMC
abstract	Biomedical applications increasingly require fully characterized new nanomaterials. There is strong evidence showing that nanomaterials not only interact with cells passively but also actively, mediating essential molecular processes for the regulation of cellular functions, but we are only starting to understand the mechanisms of those interactions. Systematic studies about cell behavior as a response to specific nanoparticle properties are scarce in the literature even when they are necessary for the rational design of medical nanodevices. Information in the literature shows that the physicochemical properties determine the bioactivity, biocompatibility, and safety of nanomaterials. The information available regarding the interaction and responses of cells to nanomaterials has not been analyzed and discussed in a single document. Hence, in this review, we present the latest advances about cellular responses to nanomaterials and integrate the available information into concrete considerations for the development of innovative, efficient, specific and, more importantly, safe biomedical nanodevices. We focus on how physicochemical nanoparticle properties (size, chemical surface, shape, charge, and topography) influence cell behavior in a first attempt to provide a practical guide for designing medical nanodevices, avoiding common experimental omissions that may lead to data misinterpretation. Finally, we emphasize the importance of the systematic study of nano–bio interactions to acquire sufficient reproducible information that allows accurate control of cell behavior based on tuning of nanomaterial properties. This information is useful to guide the design of specific nanodevices and nanomaterials to elicit desired cell responses, like targeting, drug delivery, cell attachment, differentiation, etc, or to avoid undesired side effects.
has issue date	2020-03-27(xsd:dateTime)
bibo:doi	10.1088/1361-6528/ab5bc8
bibo:pmid	31770746
has license	no-cc
sha1sum (hex)	407f7803c096776b4d4f8f5ce05a97ebe6886dff
schema:url	https://doi.org/10.1088/1361-6528/ab5bc8
resource representing a document's title	Understanding cellular interactions with nanomaterials: towards a rational design of medical nanodevices
has PubMed Central identifier	PMC7105107
has PubMed identifier	31770746
schema:publication	Nanotechnology
resource representing a document's body	covid:407f7803c096776b4d4f8f5ce05a97ebe6886dff#body_text
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