About: Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19
Creator	Van Der Schoot, Ellen Cuvalay, Susan Ghandour, Cherien Heunks, Leo Hogema, Boris Hombrink, Pleun Kragten, Natasja Nossent, Esther Oja, Anna Rispens, Theo Saris, Anno Slot, Ed Swaneveld, Francis Ten, Anja Van Lier, René Vrielink, Hans
source	BioRxiv
abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current coronavirus disease 2019 (COVID-19) pandemic. Understanding both the immunological processes providing specific immunity and potential immunopathology underlying the pathogenesis of this disease may provide valuable insights for potential therapeutic interventions. Here, we quantified SARS-CoV-2 specific immune responses in patients with different clinical courses. Compared to individuals with a mild clinical presentation, CD4+ T cell responses were qualitatively impaired in critically ill patients. Strikingly, however, in these patients the specific IgG antibody response was remarkably strong. The observed disparate T and B cell responses could be indicative of a deregulated immune response in critically ill COVID-19 patients.
has issue date	2020-06-18(xsd:dateTime)
bibo:doi	10.1101/2020.06.18.159202
has license	biorxiv
sha1sum (hex)	40897ed0606a6a0e1eba23f7690270abdfc297ff
schema:url	https://doi.org/10.1101/2020.06.18.159202
resource representing a document's title	Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19
schema:publication	bioRxiv
resource representing a document's body	covid:40897ed0606a6a0e1eba23f7690270abdfc297ff#body_text
is schema:about of	named entity 'causative' named entity 'mild' named entity 'therapeutic' named entity 'interventions' named entity 'pathogenesis' named entity 'patients' named entity 'Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)' named entity 'insights' named entity 'quantified' named entity 'patients' named entity 'responses' named entity 'immunopathology' named entity 'immune responses' named entity 'clinical presentation' named entity 'COVID' named entity 'critically ill patients' named entity 'SARS-CoV-2' named entity 'COVID-19' named entity 'adaptive immune response' named entity 'CD103' named entity 'Treg' named entity 'IL-21' named entity 'polysorbate' named entity 'IgG' named entity 'multiple comparisons' named entity 'critically ill' named entity 'COVID' named entity 'lungs' named entity 'CD103' named entity 'CMV' named entity 'cytokine' named entity 'ANOVA' named entity 'CD4+ T cells' named entity 'Peripheral blood mononuclear cells' named entity 'intensive care unit' named entity 'common cold' named entity 'critically ill' named entity 'Serum' named entity '4-1BB' named entity 'CMV' named entity 'antibody' named entity 'IgG' named entity 'ICU' named entity 'density gradient centrifugation' named entity 'PBMCs' named entity 'CD4+ T cell' named entity 'receptor binding domain' named entity 'CD4+ T cell' named entity 'ICU' named entity 'ADCC' named entity 'phenotype' named entity 'infection' named entity 'COVID' named entity 'nucleocapsid' named entity 'CD4+ T' named entity 'phenotype' named entity 'PBS' named entity 'SARS-CoV-2' named entity 'CXCR5' named entity 'antigen' named entity 'PD-1' named entity 'antibody' named entity 'nucleocapsid' named entity 'COVID' named entity 'critically ill' named entity 'antibody' named entity 'IgG' named entity 'CD4+ T cells' named entity 'peptide'

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