About: Highly conserved epitopes of DENV structural and non-structural proteins: Candidates for universal vaccine targets

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About: Highly conserved epitopes of DENV structural and non-structural proteins: Candidates for universal vaccine targets Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Highly conserved epitopes of DENV structural and non-structural proteins: Candidates for universal vaccine targets
Creator	Bhatnagar, Shradha Kumari, Kavita Lal, Rup Mittal, Nidhi Sukhralia, Shivani Verma, Mansi Dhanaraj, P Gopirajan, Shruthi
Source	Elsevier; Medline; PMC
abstract	Abstract Dengue is a severe emerging arthropod borne viral disease occurring globally. Around two fifths of the world's population, or up to 3.9 billion people, are at a risk of dengue infection. Infection induces a life-long protective immunity to the homologous serotype but confers only partial and transient protection against subsequent infection caused by other serotypes. Thus, there is a need for a vaccine which is capable of providing a life- long protection against all the serotypes of dengue virus. In our study, comparative genomics of Dengue virus (DENV) was conducted to explore potential candidates for novel vaccine targets. From our analysis we successfully found 100% conserved epitopes in Envelope protein (RCPTQGE); NS3 (SAAQRRGR, PGTSGSPI); NS4A (QRTPQDNQL); NS4B (LQAKATREAQKRA) and NS5 proteins (QRGSGQV) in all DENV serotypes. Some serotype specific conserved motifs were also found in NS1, NS5, Capsid, PrM and Envelope proteins. Using comparative genomics and immunoinformatics approach, we could find conserved epitopes which can be explored as peptide vaccine candidates to combat dengue worldwide. Serotype specific epitopes can also be exploited for rapid diagnostics. All ten proteins are explored to find the conserved epitopes in DENV serotypes, thus making it the most extensively studied viral genome so far.
has issue date	2019-05-05(xsd:dateTime)
bibo:doi	10.1016/j.gene.2019.02.001
bibo:pmid	30738967
has license	els-covid
sha1sum (hex)	409bca8a559a720f63f94a8d26a94f6524f56601
schema:url	https://doi.org/10.1016/j.gene.2019.02.001
resource representing a document's title	Highly conserved epitopes of DENV structural and non-structural proteins: Candidates for universal vaccine targets
has PubMed Central identifier	PMC7125761
has PubMed identifier	30738967
schema:publication	Gene
resource representing a document's body	covid:409bca8a559a720f63f94a8d26a94f6524f56601#body_text
is schema:about of	named entity 'severe' named entity 'viral disease' named entity 'WORLD' named entity 'TRANSIENT' named entity 'IS A' named entity 'BUT' named entity 'ARTHROPOD BORNE' named entity 'PARTIAL' named entity 'PROTECTION' named entity 'CAUSED BY' named entity 'UP TO' named entity 'VIRAL DISEASE' named entity '3.9' named entity 'SEROTYPES' named entity 'TARGETS' named entity 'GLOBALLY' named entity 'SEROTYPE' named entity 'LONG' covid:arg/409bca8a559a720f63f94a8d26a94f6524f56601 named entity 'PROTECTIVE IMMUNITY' named entity 'HIGHLY' named entity 'STRUCTURAL' named entity 'NON-STRUCTURAL PROTEINS' named entity 'CONSERVED' named entity 'VACCINE' named entity 'UNIVERSAL' named entity 'EPITOPES' named entity 'CAPABLE' named entity 'DENGUE' named entity 'LIFE' named entity 'RISK OF' named entity 'DENGUE VIRUS' named entity 'POPULATION' named entity 'NEED FOR' named entity 'INFECTION' named entity '27S' named entity 'SEVERE' named entity 'VACCINE' named entity 'SUBSEQUENT' named entity 'PROVIDING' named entity 'PEOPLE' named entity 'DENGUE INFECTION' named entity 'HOMOLOGOUS' named entity 'emerging' named entity 'Infection' named entity 'serotypes' named entity 'epitopes' named entity 'infection' named entity 'serotypes' named entity 'homologous' named entity 'non-structural proteins' named entity 'DENV' named entity 'vaccine targets' named entity 'world's population' named entity 'serotypes' named entity 'DENV' named entity 'DENV' named entity 'serotypes' named entity 'Saint Louis encephalitis virus' named entity 'vaccine' named entity 'Islam' named entity 'epitopes' named entity 'epitopes' named entity 'epitopes' named entity 'epitope' named entity 'epitopes' named entity 'plasmid DNA' named entity 'B-cell' named entity 'nonstructural proteins' named entity 'Comparative Genomics' named entity 'epitopes' named entity 'hydrophillic' named entity 'immunogen' named entity 'vaccine'

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