About: Autoimmune hepatitis-like disease in C57BL/6 mice infected with mouse hepatitis virus A59

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About: Autoimmune hepatitis-like disease in C57BL/6 mice infected with mouse hepatitis virus A59 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Autoimmune hepatitis-like disease in C57BL/6 mice infected with mouse hepatitis virus A59
Creator	Peña, Clara Retegui, Lilia Aparicio, José
Source	Elsevier; Medline; PMC
abstract	Mouse hepatitis virus A59 (MHV A59) induces autoantibodies (autoAb) to fumarylacetoacetate hydrolase (FAH), a soluble cytosolic enzyme present in the liver and kidneys, in various mouse strains. The aim of this work was to amplify and diversify the autoimmune response restricted to FAH through the use of the exogenous adjuvant called PADRE. Accordingly, C57BL/6 mice were chosen, because these animals respond to PADRE better than other mouse strains. Results presented herein indicate that, surprisingly, C57BL/6 mice developed signs of autoimmune hepatitis-like disease (AIH), including transient hypergammaglobulinemia, elevated transaminases, autoAb directed against different liver proteins and hepatic cellular infiltrates, indicating that a new model of experimental AIH could be generated by a viral inoculation. Furthermore, PADRE administration amplified the MHV effect, extending the duration of hypergammaglobulinemia and increasing the binding of autoAb as well as the degree of hepatic infiltrates. However, the adjuvant did not expand the time of the symptoms. Additionally, since plasmatic uric acid and high-mobility group box protein 1 (HGMB1) concentrations augmented in MHV- and/or PADRE-treated mice, it is suggested that both alarmins were probably involved in the spreading of the immune response induced by the viral infection and the adjuvant administration.
has issue date	2011-05-31(xsd:dateTime)
bibo:doi	10.1016/j.intimp.2011.05.020
bibo:pmid	21635973
has license	no-cc
sha1sum (hex)	40b42a7a9cd69c4d366ee2b759fbb8160e73ce40
schema:url	https://doi.org/10.1016/j.intimp.2011.05.020
resource representing a document's title	Autoimmune hepatitis-like disease in C57BL/6 mice infected with mouse hepatitis virus A59
has PubMed Central identifier	PMC7106302
has PubMed identifier	21635973
schema:publication	Int Immunopharmacol
resource representing a document's body	covid:40b42a7a9cd69c4d366ee2b759fbb8160e73ce40#body_text
is schema:about of	named entity 'A59' named entity 'C57BL/6' named entity 'disease' named entity 'DISEASE' named entity 'C57BL' named entity 'LIKE' named entity 'USE OF' named entity 'GROUP' named entity 'AMPLIFY' named entity 'URIC ACID' named entity 'TREATED' named entity 'AMPLIFIED' named entity 'INFILTRATES' named entity 'HEPATIC' named entity 'CYTOSOLIC' named entity 'CELLULAR' named entity 'DIFFERENT' named entity 'PROBABLY' named entity 'NEW' named entity 'KIDNEYS' named entity 'LIKE' named entity 'AIM' named entity 'EXOGENOUS' named entity 'INOCULATION' named entity 'MOUSE STRAINS' named entity 'ALARMINS' named entity 'RESTRICTED' named entity 'MODEL OF' named entity 'HYPERGAMMAGLOBULINEMIA' named entity 'IMMUNE RESPONSE' named entity 'VARIOUS' named entity 'C57BL' named entity 'INCREASING' named entity 'AUTOIMMUNE RESPONSE' named entity 'CHOSEN' named entity 'PROTEIN ' named entity 'FUMARYLACETOACETATE HYDROLASE' named entity 'BINDING' named entity 'SPREADING' named entity 'RESULTS' named entity 'DID' named entity 'VIRAL' named entity 'COULD BE' named entity 'AUTOIMMUNE HEPATITIS' named entity 'MICE' named entity 'INFECTED' named entity 'MOUSE HEPATITIS VIRUS' named entity 'A59' named entity 'TIME' named entity 'SOLUBLE' named entity 'EXPERIMENTAL' named entity 'PRESENT' named entity 'ANIMALS' named entity 'BETTER' named entity 'ENZYME' named entity 'TRANSIENT' named entity 'SYMPTOMS' named entity 'DISEASE' named entity 'AUTOANTIBODIES' named entity 'EXPAND' named entity 'BOX' named entity 'ADMINISTRATION' named entity 'THESE' named entity 'A59' named entity 'WORK' named entity 'MICE' named entity 'RESPOND TO' named entity 'PROTEINS' named entity 'INDUCED' named entity 'AUTOIMMUNE HEPATITIS' named entity 'DIRECTED' named entity 'FAH' named entity 'HIGH' named entity 'EXTENDING' named entity 'INDICATING' named entity 'SIGNS' named entity 'VIRAL INFECTION' named entity 'INCLUDING' named entity 'AUGMENTED'

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