About: Broad-spectrum virucidal activity of bacterial secreted lipases against flaviviruses, SARS-CoV-2 and other enveloped viruses

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About: Broad-spectrum virucidal activity of bacterial secreted lipases against flaviviruses, SARS-CoV-2 and other enveloped viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Broad-spectrum virucidal activity of bacterial secreted lipases against flaviviruses, SARS-CoV-2 and other enveloped viruses
Creator	Wang, Han Zhang, Linqi Qin, Chengfeng Zhang, Nana Cheng, Gong Yang, Yun Wang, Penghua Xiao, Xiaoping Ding, Qiang Yu, Xi Shi, Mingyu Tong, Liangqin Zhang, Liming Zhu, Yibin
source	BioRxiv
abstract	Viruses are the major aetiological agents of acute and chronic severe human diseases that place a tremendous burden on global public health and economy; however, for most viruses, effective prophylactics and therapeutics are lacking, in particular, broad-spectrum antiviral agents. Herein, we identified 2 secreted bacterial lipases from a Chromobacterium bacterium, named Chromobacterium antiviral effector-1 (CbAE-1) and CbAE-2, with a broad-spectrum virucidal activity against dengue virus (DENV), Zika virus (ZIKV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), human immunodeficiency virus (HIV) and herpes simplex virus (HSV). The CbAEs potently blocked viral infection in the extracellular milieu through their lipase activity. Mechanistic studies showed that this lipase activity directly disrupted the viral envelope structure, thus inactivating infectivity. A mutation of CbAE-1 in its lipase motif fully abrogated the virucidal ability. Furthermore, CbAE-2 presented low toxicity in vivo and in vitro, highlighting its potential as a broad-spectrum antiviral drug.
has issue date	2020-05-25(xsd:dateTime)
bibo:doi	10.1101/2020.05.22.109900
has license	biorxiv
sha1sum (hex)	415c23d07d34698dce645928705f553d4473b280
schema:url	https://doi.org/10.1101/2020.05.22.109900
resource representing a document's title	Broad-spectrum virucidal activity of bacterial secreted lipases against flaviviruses, SARS-CoV-2 and other enveloped viruses
schema:publication	bioRxiv
resource representing a document's body	covid:415c23d07d34698dce645928705f553d4473b280#body_text
is schema:about of	named entity 'Viruses' named entity 'lipase' named entity 'toxicity' named entity 'infectivity' named entity 'virucidal' named entity 'diseases' named entity 'severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)' named entity 'agents' named entity 'activity' named entity 'highlighting' named entity 'motif' named entity 'lipase' named entity 'HSV' named entity 'lipases' named entity 'herpes simplex virus' named entity 'flaviviruses' named entity 'virucidal' named entity 'blood cells' named entity 'DENV' named entity 'transmission electron microscopy' named entity 'ZIKV' named entity 'cytotoxicity' named entity 'recombinant proteins' named entity 'ZIKV' named entity 'serial dilution' named entity 'viral infection' named entity 'mosquito' named entity 'ZIKV' named entity 'virions' named entity 'lysates' named entity 'SARS-CoV-2' named entity 'virucidal' named entity 'viral disease' named entity 'Tsinghua University' named entity 'extracellular' named entity 'viral entry' named entity 'Sequence comparison' named entity 'infection' named entity 'ZIKV' named entity 'incubator' named entity 'Needleman-Wunsch' named entity 'infection' named entity 'antibiotic-antimycotic' named entity 'toxicity' named entity 'DENV' named entity 'infection' named entity 'triglyceride lipase' named entity 'infectivity' named entity 'protein' named entity 'protein' named entity 'Addgene' named entity '293T cells' named entity 'infection' named entity 'vaccines' named entity 'Addgene' named entity 'ATCC' named entity 'SINV' named entity 'lipase' named entity 'SARS-CoV-2' named entity 'Vero cells' named entity '37°C' named entity 'lipase' named entity 'cellular components' named entity 'protein' named entity 'pseudovirus' named entity 'RNase' named entity 'peptide' named entity 'centrifugation' named entity 'dimethyl sulfoxide' named entity 'HSV' named entity 'ZIKV'

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