About: EndoU is a novel regulator of AICD during peripheral B cell selection

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About: EndoU is a novel regulator of AICD during peripheral B cell selection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	EndoU is a novel regulator of AICD during peripheral B cell selection
Creator	Natarajan, Abirami Kountikov, E Kountikov, Evgueni Lykken, Jacquelyn Marchuk, Douglas Poe, J Poe, Jonathan Tedder, Thomas
source	Medline; PMC
abstract	Balanced transmembrane signals maintain a competent peripheral B cell pool limited in self-reactive B cells that may produce pathogenic autoantibodies. To identify molecules regulating peripheral B cell survival and tolerance to self-antigens (Ags), a gene modifier screen was performed with B cells from CD22-deficient C57BL/6 (CD22(−/−[B6])) mice that undergo activation-induced cell death (AICD) and fail to up-regulate c-Myc expression after B cell Ag receptor ligation. Likewise, lysozyme auto-Ag–specific B cells in Ig(Tg) hen egg lysozyme (HEL) transgenic mice inhabit the spleen but undergo AICD after auto-Ag encounter. This gene modifier screen identified EndoU, a single-stranded RNA-binding protein of ancient origin, as a major regulator of B cell survival in both models. EndoU gene disruption prevents AICD and normalizes c-Myc expression. These findings reveal that EndoU is a critical regulator of an unexpected and novel RNA-dependent pathway controlling peripheral B cell survival and Ag responsiveness that may contribute to peripheral B cell tolerance.
has issue date	2014-01-13(xsd:dateTime)
bibo:doi	10.1084/jem.20130648
bibo:pmid	24344237
has license	cc-by-nc-sa
sha1sum (hex)	41a94f21d4dc3946e1377439a2a3880fb9d33776
schema:url	https://doi.org/10.1084/jem.20130648
resource representing a document's title	EndoU is a novel regulator of AICD during peripheral B cell selection
has PubMed Central identifier	PMC3892980
has PubMed identifier	24344237
schema:publication	J Exp Med
resource representing a document's body	covid:41a94f21d4dc3946e1377439a2a3880fb9d33776#body_text
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