About: Children’s Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia

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About: Children’s Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Children’s Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia
Creator	Maitland, Kathryn Bush, Andrew Fraser, John Njuguna, Patricia Rowan, Kathy Williams, Thomas Grieve, Richard Harrison, David Bandika, Victor Engoru, Charles Kiguli, Sarah Mpoya, Ayub Olupot-Olupot, Peter Opoka, Robert Sadique, Zia
source	PMC
abstract	Background: In Africa, the clinical syndrome of pneumonia remains the leading cause of morbidity and mortality in children in the post-neonatal period. This represents a significant burden on in-patient services. The targeted use of oxygen and simple, non-invasive methods of respiratory support may be a highly cost-effective means of improving outcome, but the optimal oxygen saturation threshold that results in benefit and the best strategy for delivery are yet to be tested in adequately powered randomised controlled trials. There is, however, an accumulating literature about the harms of oxygen therapy across a range of acute and emergency situations that have stimulated a number of trials investigating permissive hypoxia. Methods: 1. Liberal oxygenation (recommended care) compared with a strategy that permits hypoxia to SpO (2 )> or = 80% (permissive hypoxia); and 2. High flow using AIrVO (2) (TM) compared with low flow delivery (routine care). Discussion: The overarching objective is to address the key research gaps in the therapeutic use of oxygen in resource-limited setting in order to provide a better evidence base for future management guidelines. The trial has been designed to address the poor outcomes of children in sub-Saharan Africa, which are associated with high rates of in-hospital mortality, 9-10% (for those with oxygen saturations of 80-92%) and 26-30% case fatality for those with oxygen saturations <80%. Clinical trial registration: ISRCTN15622505 Trial status: Recruiting
has issue date	2018-01-09(xsd:dateTime)
bibo:doi	10.12688/wellcomeopenres.12747.2
bibo:pmid	29383331
has license	cc-by
sha1sum (hex)	41f8cc392a25ac769b9d4e216b29920c1b2a7141
schema:url	https://doi.org/10.12688/wellcomeopenres.12747.2
resource representing a document's title	Children’s Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia
has PubMed Central identifier	PMC5771148
has PubMed identifier	29383331
schema:publication	Wellcome Open Res
resource representing a document's body	covid:41f8cc392a25ac769b9d4e216b29920c1b2a7141#body_text
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