About: S1 Subunit of Spike Protein from a Current Highly Virulent Porcine Epidemic Diarrhea Virus Is an Important Determinant of Virulence in Piglets

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: S1 Subunit of Spike Protein from a Current Highly Virulent Porcine Epidemic Diarrhea Virus Is an Important Determinant of Virulence in Piglets Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	S1 Subunit of Spike Protein from a Current Highly Virulent Porcine Epidemic Diarrhea Virus Is an Important Determinant of Virulence in Piglets
Creator	Enjuanes, Luis Suzuki, Tohru Ohashi, Seiichi Terada, Yutaka Kamitani, Wataru
Source	Medline; PMC
abstract	Base on the sequence of S genes, which encode spike proteins, we previously identified three different types (North American, S INDEL, and S large-DEL types) of porcine epidemic diarrhea virus (PEDV) that have re-emerged in Japan since 2013. Based on experimental infections with the North American and S large-DEL types, we also hypothesized that PEDV virulence may be linked to the S1 subunit of the S protein. To test this hypothesis, we have now assayed in gnotobiotic piglets various recombinant PEDVs generated by reverse genetics. Piglets inoculated with CV777 maintained in National Institute of Animal Health, along with piglets infected with a recombinant form of the same virus, developed subclinical to mild diarrhea. In contrast, severe watery diarrhea, dehydration, weight loss, astasia, and high mortality were observed in piglets inoculated with recombinant strains in which the S gene was partially or fully replaced with corresponding sequences from the highly virulent Japanese PEDV isolate OKN-1/JPN/2013. Indeed, symptoms resembled those in piglets inoculated with the OKN-1/JPN/2013, and were especially pronounced in younger piglets. Collectively, the data demonstrate that the S1 subunit of the S protein is an important determinant of PEDV virulence, and advance development of new vaccine candidate.
has issue date	2018-08-30(xsd:dateTime)
bibo:doi	10.3390/v10090467
bibo:pmid	30200258
has license	cc-by
sha1sum (hex)	42145eff1cc724f8e5ad1a8e04cc421512d8ec7a
schema:url	https://doi.org/10.3390/v10090467
resource representing a document's title	S1 Subunit of Spike Protein from a Current Highly Virulent Porcine Epidemic Diarrhea Virus Is an Important Determinant of Virulence in Piglets
has PubMed Central identifier	PMC6163780
has PubMed identifier	30200258
schema:publication	Viruses
resource representing a document's body	covid:42145eff1cc724f8e5ad1a8e04cc421512d8ec7a#body_text
is schema:about of	named entity 'data' named entity '2013' named entity 'sequence' named entity 'piglets' named entity 'North American' named entity 'determinant' named entity 'virulence' named entity 'Important' named entity 'IMPORTANT' named entity 'PREVIOUSLY' named entity 'DATA' named entity 'AMERICAN' named entity 'FORM' named entity 'PROTEIN ' named entity 'DETERMINANT' named entity 'A CURRENT' named entity 'NORTH AMERICAN' named entity 'ASTASIA' named entity 'STRAINS' named entity 'ISOLATE' named entity 'MAINTAINED' named entity 'EXPERIMENTAL' named entity 'HYPOTHESIS' named entity 'SYMPTOMS' named entity 'INSTITUTE' named entity 'YOUNGER' named entity 'SUBUNIT' named entity 'SEVERE' named entity 'SUBUNIT' named entity 'SEQUENCE' named entity 'NATIONAL' named entity 'ANIMAL HEALTH' named entity 'VIRULENT' named entity 'PROTEIN ' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'GENES' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'SUBCLINICAL' named entity 'DEL' named entity 'MORTALITY' named entity 'VIRULENT' named entity 'TYPES' named entity 'TO TEST' named entity 'MILD' named entity 'IMPORTANT' named entity 'DETERMINANT' named entity 'ENCODE' named entity 'REVERSE GENETICS' named entity 'DEHYDRATION' named entity 'PARTIALLY' named entity 'LARGE' named entity 'REPLACED' named entity 'SPIKE' named entity 'GENERATED' named entity 'ADVANCE' named entity 'RECOMBINANT' named entity 'MAY BE' named entity 'OBSERVED' named entity 'HAVE' named entity 'BASED' named entity 'DEVELOPMENT' named entity 'S PROTEIN' named entity 'CONTRAST' named entity 'JAPANESE' named entity 'INDEL' named entity 'INFECTED' named entity 'GENE' named entity 'VIRUS' named entity 'WATERY DIARRHEA' named entity 'DIFFERENT' named entity 'VIRULENCE' named entity 'IDENTIFIED' named entity 'HIGHLY' named entity 'JAPAN' named entity 'FULLY' named entity 'BASE' named entity 'WEIGHT LOSS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software