About: Molecular targets for the rational design of drugs to inhibit SARS coronavirus

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About: Molecular targets for the rational design of drugs to inhibit SARS coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular targets for the rational design of drugs to inhibit SARS coronavirus
Creator	Denison, Mark Brockway, Sarah
Source	Elsevier; Medline; PMC
abstract	Despite years of research, the precise determinants of coronavirus replication and pathogenesis remain unidentified. What is known of the pathogenesis of the severe acute respiratory syndrome coronavirus (SARS-CoV) is limited, but clinical observations suggest that both viral-induced cytotoxicity and host immune-mediated destruction contribute to the severity of disease. This summary discusses recent advances in coronavirus research that will facilitate the identification of crucial molecular targets for the rational design of SARS therapeutics.
has issue date	2004-10-03(xsd:dateTime)
bibo:doi	10.1016/j.ddmec.2004.08.016
bibo:pmid	32288772
has license	no-cc
sha1sum (hex)	42374ef16d1860a5d1b3501044d5e05d51dd6e5f
schema:url	https://doi.org/10.1016/j.ddmec.2004.08.016
resource representing a document's title	Molecular targets for the rational design of drugs to inhibit SARS coronavirus
has PubMed Central identifier	PMC7105069
has PubMed identifier	32288772
schema:publication	Drug Discov Today Dis Mech
resource representing a document's body	covid:42374ef16d1860a5d1b3501044d5e05d51dd6e5f#body_text
is schema:about of	named entity 'SARS CORONAVIRUS' named entity 'TO INHIBIT' named entity 'BUT' named entity 'SUMMARY' named entity 'LIMITED' named entity 'INDUCED' named entity 'CONTRIBUTE ' named entity 'DESTRUCTION' named entity 'RECENT' named entity 'MOLECULAR' named entity 'UNIDENTIFIED' named entity 'IMMUNE-MEDIATED' named entity 'PRECISE' named entity 'SARS' named entity 'DESIGN' named entity 'DISEASE' named entity 'HOST' named entity 'SUGGEST' named entity 'SEVERITY' named entity 'CYTOTOXICITY' named entity 'DESIGN' named entity 'MOLECULAR' named entity 'PATHOGENESIS' named entity 'DRUGS' named entity 'OBSERVATIONS' named entity 'TARGETS' named entity 'TARGETS' named entity 'YEARS' named entity 'THERAPEUTICS' named entity 'KNOWN' named entity 'WHAT' named entity 'IDENTIFICATION' named entity 'CLINICAL' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'DETERMINANTS' named entity 'VIRAL-' named entity 'RESEARCH' named entity 'host' named entity 'targets' named entity 'cytotoxicity' named entity 'SARS' named entity 'rational design of drugs' named entity 'MHV' named entity 'cell culture' named entity 'SARS' named entity 'immune cells' named entity 'virus' named entity 'rational design' named entity 'steroid' named entity 'coronavirus' named entity 'SARS' named entity 'apoptosis' named entity 'multi-nucleated' named entity 'atypical pneumonia' named entity 'cytoplasm' named entity 'SARS' named entity 'SARS coronavirus' named entity 'viruses' named entity 'INFa' named entity 'SARS-CoV' named entity 'SARS-CoV' named entity 'ribavirin' named entity 'antibody' named entity 'monocytes' named entity 'MHV' named entity 'cell surface' named entity 'mice' named entity 'ritonavir' named entity 'proteinase' named entity 'SARS' named entity 'receptor' named entity 'incubation period' named entity 'immune cells' named entity 'SARS' named entity 'virions' named entity 'cellular processes' named entity 'neuropathology' named entity 'pathogenesis' named entity 'viral replication' named entity 'human pathogens'

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