About: The replication of a mouse adapted SARS-CoV in a mouse cell line stably expressing the murine SARS-CoV receptor mACE2 efficiently induces the expression of proinflammatory cytokines

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About: The replication of a mouse adapted SARS-CoV in a mouse cell line stably expressing the murine SARS-CoV receptor mACE2 efficiently induces the expression of proinflammatory cytokines Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The replication of a mouse adapted SARS-CoV in a mouse cell line stably expressing the murine SARS-CoV receptor mACE2 efficiently induces the expression of proinflammatory cytokines
Creator	Enjuanes, Luis Gallagher, Thomas Dediego, Marta Jimenez-Guardeño, Jose Nieto-Torres, Jose Regla-Nava, Jose
source	Elsevier; Medline; PMC
abstract	Infection of conventional mice with a mouse adapted (MA15) severe acute respiratory syndrome (SARS) coronavirus (CoV) reproduces many aspects of human SARS such as pathological changes in lung, viremia, neutrophilia, and lethality. However, established mouse cell lines highly susceptible to mouse-adapted SARS-CoV infection are not available. In this work, efficiently transfectable mouse cell lines stably expressing the murine SARS-CoV receptor angiotensin converting enzyme 2 (ACE2) have been generated. These cells yielded high SARS-CoV-MA15 titers and also served as excellent tools for plaque assays. In addition, in these cell lines, SARS-CoV-MA15 induced the expression of proinflammatory cytokines and IFN-β, mimicking what has been observed in experimental animal models infected with SARS-CoV and SARS patients. These cell lines are valuable tools to perform in vitro studies in a mouse cell system that reflects the species used for in vivo studies of SARS-CoV-MA15 pathogenesis.
has issue date	2013-11-01(xsd:dateTime)
bibo:doi	10.1016/j.jviromet.2013.07.039
bibo:pmid	23911968
has license	bronze-oa
sha1sum (hex)	42708c1a2725c0ddee310e8eaecb0b1f247fdded
schema:url	https://doi.org/10.1016/j.jviromet.2013.07.039
resource representing a document's title	The replication of a mouse adapted SARS-CoV in a mouse cell line stably expressing the murine SARS-CoV receptor mACE2 efficiently induces the expression of proinflammatory cytokines
has PubMed Central identifier	PMC3805046
has PubMed identifier	23911968
schema:publication	Journal of Virological Methods
resource representing a document's body	covid:42708c1a2725c0ddee310e8eaecb0b1f247fdded#body_text
is schema:about of	named entity 'These' named entity 'generated' named entity 'PATIENTS' named entity 'RECEPTOR' named entity 'HIGH' named entity 'EXCELLENT' named entity 'EXPRESSION' named entity 'A MOUSE' named entity 'SARS-COV' named entity 'EXPERIMENTAL ANIMAL MODELS' named entity 'INFECTED' named entity 'HAVE' named entity 'IN VIVO STUDIES' named entity 'OBSERVED' named entity 'PROINFLAMMATORY CYTOKINES' named entity 'MOUSE CELL' named entity 'SPECIES' named entity 'EXPRESSION' named entity 'RECEPTOR' named entity 'MOUSE' named entity 'MURINE' named entity 'REPLICATION' named entity 'ADAPTED' named entity 'SARS-COV' named entity 'PROINFLAMMATORY CYTOKINES' named entity 'MOUSE CELL LINE' named entity 'PATHOGENESIS' named entity 'CONVENTIONAL' named entity 'PLAQUE' named entity 'IN VITRO STUDIES' named entity 'TOOLS' named entity 'ADAPTED' named entity 'A MOUSE' named entity 'CELL LINES' named entity 'HUMAN' named entity 'PERFORM' named entity 'PATHOLOGICAL' named entity 'MURINE' named entity 'SARS' named entity 'CELL SYSTEM' named entity 'NOT AVAILABLE' named entity 'CHANGES' named entity 'REFLECTS' named entity 'IFN' named entity 'GENERATED' named entity 'HIGHLY' named entity 'SUSCEPTIBLE' named entity 'ESTABLISHED' named entity 'ANIMAL MODELS ' named entity 'LUNG' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'WHAT' named entity 'CELLS' named entity 'MICE' named entity 'THESE' named entity 'INFECTION' named entity 'VIREMIA' named entity 'INDUCED' named entity 'WORK' named entity 'CORONAVIRUS' named entity 'NEUTROPHILIA' named entity 'ADDITION' named entity 'ANGIOTENSIN CONVERTING ENZYME 2' named entity 'LETHALITY' named entity 'USED' named entity 'MACE2' covid:arg/42708c1a2725c0ddee310e8eaecb0b1f247fdded named entity 'However' named entity 'infection' named entity 'infected' named entity 'perform' named entity 'aspects' named entity 'lung' named entity 'models' named entity 'tools' named entity 'IFN'

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