About: Tula hantavirus triggers pro-apoptotic signals of ER stress in Vero E6 cells

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Tula hantavirus triggers pro-apoptotic signals of ER stress in Vero E6 cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Tula hantavirus triggers pro-apoptotic signals of ER stress in Vero E6 cells
Creator	Vaheri, Antti Lankinen, Hilkka Vapalahti, Olli Li, Xiao-Dong Putkuri, Niina
Source	Elsevier; Medline; PMC
abstract	Abstract Tula virus is a member of the Hantavirus genus of the family Bunyaviridae. Viruses of this family have an unusual pattern of intracellular maturation at the ER–Golgi compartment. We recently found that Tula virus, similar to several other hantaviruses, is able to induce apoptosis in cultured cells [Li, X.D., Kukkonen, S., Vapalahti, O., Plyusnin, A., Lankinen, H., Vaheri, A., 2004. Tula hantavirus infection of Vero E6 cells induces apoptosis involving caspase 8 activation. J. Gen. Virol. 85, 3261–3268.]. However, the cellular mechanisms remain to be clarified. In this study, we demonstrate that the progressive replication of Tula virus in Vero E6 cells initiates several death programs that are intimately associated with ER stress: (1) early activation of ER-resident caspase-12; (2) phosphorylation of Jun NH2-terminal kinase (JNK) and its downstream target transcriptional factor, c-jun; (3) induction of the pro-apoptotic transcriptional factor, growth arrest- and DNA damage-inducible gene 153, or C/EBP homologous protein (Gadd153/chop); and (4) changes in the ER-membrane protein BAP31 implying cross-talk with the mitochondrial apoptosis pathway. Furthermore, we confirmed that a sustained ER stress was induced marked by an increased expression of an ER chaperone Grp78/BiP. Taken together, we have identified involvement of ER stress-mediated death program in Tula virus-infected Vero E6 cells which provides a new approach to understand the mechanisms in hantavirus-induced apoptosis.
has issue date	2005-03-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2005.01.002
bibo:pmid	15708603
has license	els-covid
sha1sum (hex)	4271c5e7415004305cddecd008172888fa06048a
schema:url	https://doi.org/10.1016/j.virol.2005.01.002
resource representing a document's title	Tula hantavirus triggers pro-apoptotic signals of ER stress in Vero E6 cells
has PubMed Central identifier	PMC7173054
has PubMed identifier	15708603
schema:publication	Virology
resource representing a document's body	covid:4271c5e7415004305cddecd008172888fa06048a#body_text
is schema:about of	named entity 'apoptosis' named entity 'caspase' named entity 'mitochondrial' named entity 'triggers' named entity 'TAKEN' named entity 'SUSTAINED' named entity 'RECENTLY' named entity 'STUDY' named entity 'JUN' named entity 'PROGRAMS' named entity 'INDUCED' named entity 'HANTAVIRUS INFECTION' named entity 'APOPTOSIS' named entity 'GOLGI' named entity 'APPROACH' named entity 'UNDERSTAND' named entity 'PHOSPHORYLATION' named entity 'cultured cells' named entity 'Hantavirus' named entity 'terminal' named entity 'signals' named entity 'intracellular' named entity 'Jun' named entity 'ER stress' named entity 'protein' named entity 'caspase 8' named entity 'phosphorylation' named entity 'BiP' named entity 'mitochondrial' named entity 'JNK' named entity 'C/EBP' named entity 'cross-talk' named entity 'BiP' named entity 'Kopito' named entity 'Tula virus' named entity 'BiP/Grp78' named entity 'nucleocapsid' named entity 'C/EBP' named entity 'signaling pathways' named entity 'nucleocapsid protein' named entity 'Vero E6' named entity 'IL-6' named entity 'mitochondria' named entity 'Vero E6' named entity 'pro-enzyme' named entity 'hantavirus pulmonary syndrome' named entity 'BiP protein' named entity 'staining' named entity 'unfolded or misfolded proteins' named entity 'Bcl-2' named entity 'transcriptional' named entity 'Caspase' named entity 'TNF-a' named entity 'Tula hantavirus' named entity 'actin' named entity 'glucose-regulated protein' named entity 'coronaviruses' named entity 'IFN-a' named entity 'homologous protein' named entity 'substrate' named entity 'Santa Cruz Biotechnology' named entity 'Tula virus' named entity 'polyclonal antibodies' named entity 'mycoplasma' named entity 'endotoxins' named entity 'AP-1' named entity 'death receptor' named entity 'high molecular weight' named entity 'misfolding' named entity 'infection' named entity 'protein' named entity 'Vero E6' named entity 'phosphorylated' named entity 'Vero E6 cells' named entity 'hantaviruses' named entity 'stress response' named entity 'cytosolic'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software