About: Identification of novel ligands for the RNA pseudoknot that regulate −1 ribosomal frameshifting

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About: Identification of novel ligands for the RNA pseudoknot that regulate −1 ribosomal frameshifting Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of novel ligands for the RNA pseudoknot that regulate −1 ribosomal frameshifting
Creator	Park, Hyun-Ju Kim, Yang-Gyun Park, So-Jung Jung, Young
Source	Elsevier; Medline; PMC
abstract	Abstract In many viruses, −1 ribosomal frameshifting (−1RF) regulates synthesis of proteins and is crucial for virus production. An RNA pseudoknot is one of the essential components of the viral −1RF system. Thermodynamic or kinetic control of pseudoknot folding may be important in regulating the efficiency of −1RF. Thus, small molecules that interact with viral RNA pseudoknots may disrupt the −1RF system and show antiviral activity. In this study, we conducted virtual screening of a chemical database targeting the X-ray crystal structure of RNA pseudoknot complexed with biotin to identify ligands that may regulate an −1RF system containing biotin-aptamer as an RNA pseudoknot component. After docking screening of about 80,000 compounds, 58 high-ranked hits were selected and their activities were examined by in vitro and cell-based −1 frameshifting assays. Six compounds increased the efficiency of −1 frameshifting, and these are novel small molecule compounds that regulate the −1RF.
has issue date	2008-04-15(xsd:dateTime)
bibo:doi	10.1016/j.bmc.2008.02.025
bibo:pmid	18321712
has license	els-covid
sha1sum (hex)	431fc9230623636631c77dfb070264ac6f708b97
schema:url	https://doi.org/10.1016/j.bmc.2008.02.025
resource representing a document's title	Identification of novel ligands for the RNA pseudoknot that regulate −1 ribosomal frameshifting
has PubMed Central identifier	PMC7125880
has PubMed identifier	18321712
schema:publication	Bioorganic & Medicinal Chemistry
resource representing a document's body	covid:431fc9230623636631c77dfb070264ac6f708b97#body_text
is schema:about of	named entity 'REGULATE' named entity 'screening' named entity 'ligands' named entity 'study' named entity 'TO IDENTIFY' named entity 'HITS' named entity 'STUDY' named entity 'PSEUDOKNOTS' named entity 'APTAMER' named entity 'DOCKING' named entity 'DATABASE' named entity 'INTERACT' named entity 'SYSTEM' named entity 'IN VITRO' named entity 'INCREASED' named entity 'SYNTHESIS' named entity 'REGULATING' named entity 'PROTEINS' named entity '80%' named entity 'NOVEL' named entity 'VIRUSES' named entity 'SCREENING' named entity 'ANTIVIRAL ACTIVITY' named entity 'BASED' named entity 'PSEUDOKNOT' named entity 'DISRUPT' named entity 'VIRAL' named entity 'VIRUS PRODUCTION' named entity 'KINETIC' named entity 'RNA' named entity 'CHEMICAL' named entity 'IDENTIFICATION' named entity 'THESE' named entity 'EXAMINED' named entity 'RIBOSOMAL' named entity 'VIRAL RNA' named entity 'ONE OF' named entity 'X-RAY' named entity 'VIRTUAL SCREENING' named entity 'ESSENTIAL' named entity 'COMPONENT' named entity 'EFFICIENCY' named entity 'IMPORTANT' named entity 'CELL' covid:arg/431fc9230623636631c77dfb070264ac6f708b97 named entity 'THERMODYNAMIC' named entity 'CONTROL' named entity 'COMPONENTS' named entity 'SMALL MOLECULE' named entity 'FOLDING' named entity 'NOVEL' named entity 'RIBOSOMAL' named entity 'THEIR' named entity 'CRYSTAL STRUCTURE' named entity 'SELECTED' named entity 'LIGANDS' named entity 'SMALL MOLECULES' named entity 'PSEUDOKNOT' named entity 'ABOUT' named entity 'ACTIVITIES' named entity 'CONTAINING' named entity 'REGULATE' named entity 'TARGETING' named entity 'BIOTIN' named entity 'LIGANDS' named entity 'RNA' named entity 'MAY BE' named entity 'system' named entity 'targeting' named entity 'proteins' named entity 'small molecules' named entity 'hits' named entity 'compounds' named entity 'compounds' named entity 'pseudoknot' named entity 'pseudoknot' named entity 'biotin' named entity 'regulate'

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