About: Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome

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About: Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome
Creator	Zhang, Ying Dong, Tao Kang, Tang Wei, Ye Xin, Wei Ying, Zhang Chang-Xing, Huang Chuan-Tao, Ye Chun-Mei, Zhang Cn, † Hong-Wei, Ma Kang, Hong-Wei M Kufer, Thomas Nakao, Miki Pei-Yu, Bian Planz, Oliver Wang, Ping-Zhong Xu-Yang, Zheng Xue-Fan, Bai Ying-Feng, Lei Zhan-Sheng, Jia Zheng, Xu-Yang
Source	Medline; PMC
abstract	Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS). Previous studies have identified interferon-induced transmembrane proteins (IFITMs) as an interferon-stimulated gene family. However, the role of IFITMs in HTNV infection is unclear. In this study, we observed that IFITM3 single nucleotide polymorphisms (SNP) rs12252 C allele and CC genotype associated with the disease severity and HTNV load in the plasma of HFRS patients. In vitro experiments showed that the truncated protein produced by the rs12252 C allele exhibited an impaired anti-HTNV activity. We also proved that IFITM3 was able to inhibit HTNV infection in both HUVEC and A549 cells by overexpression and RNAi assays, likely via a mechanism of inhibiting virus entry demonstrated by binding and entry assay. Localization of IFITM3 in late endosomes was also observed. In addition, we demonstrated that the transcription of IFITM3 is negatively regulated by an lncRNA negative regulator of interferon response (NRIR). Taken together, we conclude that IFITM3, negatively regulated by NRIR, inhibits HTNV infection, and its SNP rs12252 correlates with the plasma HTNV load and the disease severity of patients with HFRS.
has issue date	2017-01-03(xsd:dateTime)
bibo:doi	10.3389/fimmu.2016.00535
bibo:pmid	28096800
has license	cc-by
sha1sum (hex)	4328e18bdf9b52875c87f3f5ddb1911636a192d2
schema:url	https://doi.org/10.3389/fimmu.2016.00535
resource representing a document's title	Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome
has PubMed Central identifier	PMC5206578
has PubMed identifier	28096800
schema:publication	Front Immunol
resource representing a document's body	covid:4328e18bdf9b52875c87f3f5ddb1911636a192d2#body_text
is schema:about of	named entity 'HEMORRHAGIC FEVER WITH RENAL SYNDROME' named entity 'binding' named entity 'produced' named entity 'observed' named entity 'inhibits' named entity 'single' named entity 'CC GENOTYPE' named entity 'LOAD' named entity 'STUDY' named entity 'BINDING' named entity 'INHIBITING' named entity 'NEGATIVE REGULATOR' named entity 'A549 CELLS' named entity 'SEVERITY' named entity 'EXPERIMENTS' named entity 'ENDOSOMES' named entity 'HANTAAN VIRUS' named entity 'RNAI' named entity 'HFRS' named entity 'INTERFERON' named entity 'ADDITION' named entity 'PROTEIN ' named entity 'INDUCED' named entity 'IFITM3' named entity 'PREVIOUS' named entity 'ASSOCIATED WITH' named entity 'SNP' named entity 'DISEASE SEVERITY' named entity 'STUDIES' named entity 'RESPONSE' named entity 'ITS' named entity 'HUVEC' named entity 'OBSERVED' named entity 'OVEREXPRESSION' named entity 'TAKEN' named entity 'CAUSES' named entity 'LNCRNA' named entity 'CONCLUDE' named entity 'TRANSCRIPTION' named entity 'MECHANISM' named entity 'ACTIVITY' named entity 'PLASMA' named entity 'VIRUS ENTRY' named entity 'TRANSMEMBRANE PROTEINS' named entity 'ROLE' named entity 'ALLELE' named entity 'HANTAAN VIRUS' named entity 'TRUNCATED' named entity 'VIRUS INFECTION' named entity 'ITS' named entity 'TO INHIBIT' named entity 'LATE' named entity 'HEMORRHAGIC FEVER WITH RENAL SYNDROME' named entity 'LOCALIZATION' named entity 'IN VITRO' named entity 'STIMULATED' named entity 'HAVE' named entity 'REGULATED' named entity 'SINGLE NUCLEOTIDE POLYMORPHISM' named entity 'INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 3'

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