About: “Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

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About: “Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)
Creator	Edis, Zehra Haj Bloukh, Samir Ibrahim, May Sara, Hamed
source	Medline; PMC
abstract	The emergence of resistant pathogens is a burden on mankind and threatens the existence of our species. Natural and plant-derived antimicrobial agents need to be developed in the race against antibiotic resistance. Nanotechnology is a promising approach with a variety of products. Biosynthesized silver nanoparticles (AgNP) have good antimicrobial activity. We prepared AgNPs with trans-cinnamic acid (TCA) and povidone–iodine (PI) with increased antimicrobial activity. We synthesized also AgNPs with natural cinnamon bark extract (Cinn) in combination with PI and coated biodegradable Polyglycolic Acid (PGA) sutures with the new materials separately. These compounds (TCA-AgNP, TCA-AgNP-PI, Cinn-AgNP, and Cinn-AgNP-PI) and their dip-coated PGA sutures were tested against 10 reference strains of microorganisms and five antibiotics by zone inhibition with disc- and agar-well-diffusion methods. The new compounds TCA-AgNP-PI and Cinn-AgNP-PI are broad spectrum microbicidal agents and therefore potential coating materials for sutures to prevent Surgical Site Infections (SSI). TCA-AgNP-PI inhibits the studied pathogens stronger than Cinn-AgNP-PI in-vitro and on coated sutures. Dynamic light scattering (DLS), ultraviolet-visible spectroscopy (UV-Vis), Fourier Transform infrared spectroscopy (FT-IR), Raman, X-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) confirmed the composition of TCA-AgNP-PI and Cinn-AgNP-PI. Smart solutions involving hybrid materials based on synergistic antimicrobial action have promising future perspectives to combat resistant microorganisms.
has issue date	2020-04-15(xsd:dateTime)
bibo:doi	10.3390/pharmaceutics12040361
bibo:pmid	32326601
has license	cc-by
sha1sum (hex)	432b3ad5cb479b1590274895405363dd87943880
schema:url	https://doi.org/10.3390/pharmaceutics12040361
resource representing a document's title	“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)
has PubMed Central identifier	PMC7238257
has PubMed identifier	32326601
schema:publication	Pharmaceutics
resource representing a document's body	covid:432b3ad5cb479b1590274895405363dd87943880#body_text
is schema:about of	named entity 'Nanotechnology' named entity 'synergistic' named entity 'resistant' named entity 'Site' named entity 'microorganisms' named entity 'TCA' named entity 'XRD' named entity 'antimicrobial' named entity 'SSI' named entity 'sutures' named entity 'Dynamic light scattering' named entity 'zone' named entity 'agents' named entity 'cinnamon' named entity 'plant extract' named entity 'Hydrogen bonding' named entity 'TCA' named entity 'E. faecalis' named entity 'PVP' named entity 'S. aureus' named entity 'plasmon' named entity 'aqueous' named entity 'ATCC' named entity 'TCA' named entity 'DLS' named entity 'solid-state laser' named entity 'P. aeruginosa' named entity 'TCA' named entity 'microbial growth' named entity 'K. pneumoniae' named entity 'mortality rates' named entity 'adsorption' named entity 'biocidal' named entity 'broad peak' named entity 'Iodine' named entity 'trans-cinnamic acid' named entity 'C. albicans' named entity '430 nm' named entity 'antimicrobial' named entity 'TCA' named entity 'nanoparticle' named entity 'antibiotics' named entity 'silver nanoparticles' named entity 'antimicrobials' named entity 'P. aeruginosa' named entity 'pathogens' named entity 'E.coli' named entity 'plant extract' named entity 'TCA' named entity 'sharp peak' named entity 'TCA' named entity 'P. aeruginosa' named entity 'cinnamaldehyde' named entity 'B. subtilis' named entity 'TCA' named entity 'Electrostatic' named entity 'TCA' named entity 'sharp peak' named entity 'absorbance' named entity 'human health' named entity 'crystallinity' named entity 'negative charge' named entity 'TCA' named entity 'TCA' named entity 'C. albicans' named entity 'mmol' named entity 'carbonyl groups' named entity 'hydrophilic' named entity 'nucleation' named entity 'XRD' named entity 'antibiotics' named entity 'Gram-negative' named entity 'TCA' named entity 'monochromator' named entity 'Van der Waals' named entity 'silver nitrate' named entity 'Gram-negative bacteria' named entity 'strong peak'

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