About: Commensal enteric bacteria lipopolysaccharide impairs host defense against disseminated Candida albicans fungal infection

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About: Commensal enteric bacteria lipopolysaccharide impairs host defense against disseminated Candida albicans fungal infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Commensal enteric bacteria lipopolysaccharide impairs host defense against disseminated Candida albicans fungal infection
Creator	Chaturvedi, Vandana Xin, Lijun Clark, Dayna Ertelt, James Jiang, Tony Kinder, Jeremy Way, Sing
Source	Medline; PMC
abstract	Commensal enteric bacteria maintain systemic immune responsiveness that protects against disseminated or localized infection in extra-intestinal tissues caused by pathogenic microbes. However, since shifts in infection susceptibility after commensal bacteria eradication have primarily been probed using viruses, the broader applicability to other pathogen types remains undefined. In sharp contrast to diminished antiviral immunity, we show commensal bacteria eradication bolsters protection against disseminated Candida albicans fungal infection. Enhanced antifungal immunity reflects more robust systemic expansion of Ly6G(hi)Ly6C(int) neutrophils, and their mobilization into infected tissues among antibiotic treated compared with commensal bacteria replete control mice. Reciprocally, depletion of neutrophils from expanded levels or intestinal LPS reconstitution overrides the antifungal protective benefits conferred by commensal bacteria eradication. This discordance in antifungal compared with antiviral immunity highlights intrinsic differences in how commensal bacteria control responsiveness for specific immune cell subsets because pathogen-specific CD8(+) T cells that protect against viruses were suppressed similarly after C. albicans and influenza A virus infection. Thus, positive calibration of antiviral immunity by commensal bacteria is counterbalanced by restrained activation of other immune components that confer antifungal immunity.
has issue date	2014-12-10(xsd:dateTime)
bibo:doi	10.1038/mi.2014.119
bibo:pmid	25492473
has license	no-cc
sha1sum (hex)	433adf76ea9adc9f5c540d4c28142d4d020969e2
schema:url	https://doi.org/10.1038/mi.2014.119
resource representing a document's title	Commensal enteric bacteria lipopolysaccharide impairs host defense against disseminated Candida albicans fungal infection
has PubMed Central identifier	PMC4465067
has PubMed identifier	25492473
schema:publication	Mucosal Immunol
resource representing a document's body	covid:433adf76ea9adc9f5c540d4c28142d4d020969e2#body_text
is schema:about of	named entity 'FUNGAL INFECTION' named entity 'Thus' named entity 'This' named entity 'immunity' named entity 'activation' named entity 'eradication' named entity 'tissues' named entity 'counterbalanced' named entity 'LIPOPOLYSACCHARIDE' named entity 'ENTERIC BACTERIA' named entity 'LOCALIZED INFECTION' named entity 'BENEFITS' named entity 'COMMENSAL BACTERIA' named entity 'SHIFTS' named entity 'TYPES' named entity 'ROBUST' named entity 'INFECTED' named entity 'NEUTROPHILS' named entity 'LY6G' named entity 'UNDEFINED' named entity 'CANDIDA ALBICANS' named entity 'INT' named entity 'REPLETE' named entity 'ACCESS' named entity 'HOST DEFENSE' named entity 'HAVE' named entity 'LPS' named entity 'CONTRAST' named entity 'CALIBRATION' named entity 'BOLSTERS' named entity 'CAUSED BY' named entity 'RESPONSIVENESS' named entity 'REFLECTS' named entity 'DISSEMINATED' named entity 'IMPAIRS' named entity 'PUBLIC' named entity 'HHS' named entity 'ENTERIC BACTERIA' named entity 'CANDIDA ALBICANS' named entity 'THEIR' named entity 'ANTIFUNGAL' named entity 'T CELLS' named entity 'LEVELS' named entity 'PROBED' named entity 'SYSTEMIC' named entity 'CONTROL' named entity 'INTRINSIC' named entity 'INTESTINAL' named entity 'MICE' named entity 'ANTIVIRAL' named entity 'SUSCEPTIBILITY' named entity 'DISCORDANCE' named entity 'ENHANCED' named entity 'EXTRA' named entity 'IMMUNE' named entity 'COMPARED' named entity 'LY6C' named entity 'BACTERIA ' named entity 'COMMENSAL' named entity 'DISSEMINATED CANDIDA' named entity 'TREATED' named entity 'TISSUES' named entity 'ANTIBIOTIC' named entity 'COMPONENTS' named entity 'EXPANSION' named entity 'PATHOGENIC' named entity 'SHARP' named entity 'INFLUENZA A VIRUS INFECTION' named entity 'PROTECTION' named entity 'MOBILIZATION' named entity 'EXPANDED ' named entity 'RECONSTITUTION' named entity 'DIMINISHED' named entity 'FUNGAL INFECTION' named entity 'IMMUNITY'

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