About: The influence of age and genetics on natural resistance to experimentally induced feline infectious peritonitis

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About: The influence of age and genetics on natural resistance to experimentally induced feline infectious peritonitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The influence of age and genetics on natural resistance to experimentally induced feline infectious peritonitis
Creator	Liu, Hongwei Gandolfi, Barbara Lyons, Leslie Pedersen, Niels
Source	Elsevier; Medline; PMC
abstract	Naturally occurring feline infectious peritonitis (FIP) is usually fatal, giving the impression that immunity to the FIP virus (FIPV) is extremely poor. This impression may be incorrect, because not all cats experimentally exposed to FIPV develop FIP. There is also a belief that the incidence of FIP may be affected by a number of host, virus, and environmental cofactors. However, the contribution of these cofactors to immunity and disease incidence has not been determined. The present study followed 111 random-bred specific pathogen free (SPF) cats that were obtained from a single research breeding colony and experimentally infected with FIPV. The cats were from several studies conducted over the past 5 years, and as a result, some of them had prior exposure to feline enteric coronavirus (FECV) or avirulent FIPVs. The cats were housed under optimized conditions of nutrition, husbandry, and quarantine to eliminate most of the cofactors implicated in FIPV infection outcome and were uniformly challenge exposed to the same field strain of serotype 1 FIPV. Forty of the 111 (36%) cats survived their initial challenge exposure to a Type I cat-passaged field strains of FIPV. Six of these 40 survivors succumbed to FIP to a second or third challenge exposure, suggesting that immunity was not always sustained. Exposure to non-FIP-inducing feline coronaviruses prior to challenge with virulent FIPV did not significantly affect FIP incidence but did accelerate the disease course in some cats. There were no significant differences in FIP incidence between males and females, but resistance increased significantly between 6 months and 1 or more years of age. Genetic testing was done on 107 of the 111 infected cats. Multidimensional scaling (MDS) segregated the 107 cats into three distinct families based primarily on a common sire(s), and resistant and susceptible cats were equally distributed within each family. Genome-wide association studies (GWAS) on 73 cats that died of FIP after one or more exposures (cases) and 34 cats that survived (controls) demonstrated four significant associations after 100k permutations. When these same cats were analyzed using a sib-pair transmission test, three of the four associations were confirmed although not with genome-wide significance. GWAS was then done on three different age groups of cases to take into account age-related resistance, and different associations were observed. The only common and strong association identified between the various GWAS case configurations was for the 34.7–45.8 Mb region of chromosome A3. No obvious candidate genes were present in this region.
has issue date	2014-11-15(xsd:dateTime)
bibo:doi	10.1016/j.vetimm.2014.09.001
bibo:pmid	25265870
has license	no-cc
sha1sum (hex)	434de40634a539fc41ac568d5de5ed6f9057ad39
schema:url	https://doi.org/10.1016/j.vetimm.2014.09.001
resource representing a document's title	The influence of age and genetics on natural resistance to experimentally induced feline infectious peritonitis
has PubMed Central identifier	PMC7112829
has PubMed identifier	25265870
schema:publication	Vet Immunol Immunopathol
resource representing a document's body	covid:434de40634a539fc41ac568d5de5ed6f9057ad39#body_text
is schema:about of	named entity 'This' named entity 'females' named entity 'associations' named entity 'cats' named entity 'Naturally' named entity 'survivors' named entity 'conditions' named entity 'FIP' named entity 'FIP' named entity 'disease' covid:arg/434de40634a539fc41ac568d5de5ed6f9057ad39 named entity 'enteric' named entity 'disease' named entity 'experimentally' named entity 'account' named entity 'coronavirus' named entity 'study' named entity 'MDS' named entity 'permutations' named entity 'There' named entity 'males' named entity 'FIPV' named entity 'virus' named entity 'resistance' named entity 'FIPV' named entity 'husbandry' named entity 'immunity' named entity 'FIPV' named entity 'FIP' named entity 'specific pathogen free' named entity 'FIPV' named entity 'serotype' named entity 'FIP' named entity 'age-related' named entity 'FIP' named entity 'FIPV' named entity 'feline infectious peritonitis' named entity 'natural resistance' named entity 'breeding stock' named entity 'virus' named entity 'FIPV' named entity 'genetics' named entity 'virulent' named entity 'control group' named entity 'virulent' named entity 'FIPV' named entity 'infection' named entity '85%' named entity 'FIPV' named entity 'cofactors' named entity 'fever' named entity 'cofactors' named entity 'Fisher's exact test' named entity 'Manhattan' named entity 'SNPs' named entity 'heritability' named entity 'vaccination' named entity 'cofactors' named entity 'genetic factors' named entity 'infection' named entity 'antibody' named entity 'FIPV' named entity 'FIPV' named entity 'tuberculosis' named entity 'FIP' named entity 'IgG' named entity 'vaccine' named entity 'signs of disease' named entity 'FIPV' named entity 'fever' named entity 'infection' named entity 'USDA' named entity 'linkage disequilibrium' named entity 'cofactors' named entity 'Rectal' named entity 'genome-wide' named entity 'FIP' named entity 'FIPV'

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