About: Evaluation of the synergetic effect of Yupingfeng san and Flos Sophorae Immaturus based on free radical scavenging capacity

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About: Evaluation of the synergetic effect of Yupingfeng san and Flos Sophorae Immaturus based on free radical scavenging capacity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of the synergetic effect of Yupingfeng san and Flos Sophorae Immaturus based on free radical scavenging capacity
Creator	Zhang, Li Zhang, Wei Zhao, Ling Zhang, Yanli Lin, Yuan Shi, Fei Zhang, Y Fu, Hualin Huang, Ruoyue Lin, Juchun Pei, Linlin Peng, Guangneng Shu, Gang Zhang, Huang Yuan, Zhixiang Zhang, Yuning
Source	Elsevier; Medline; PMC
abstract	OBJECTIVE: This study aimed to determine the optimal extraction process and examine whether the combination ofFlos Sophorae Immaturus (FSI) and Yupingfeng san (YPS) has a synergistic effect on free radical scavenging capacity. DESIGN AND METHODS: The time of immersion and extraction and the ratios (material/solvent) of the combination of YPS and FSI were optimized on the basis of polysaccharide and flavonoid yields via orthogonal design. The optimal result was used in the 1,1-diphenyl-1-picrylhydrazyl (DPPH) assay and animal experiments to test the antioxidant activity, which is reflected by superoxide dismutase, malondialdehyde, glutathione peroxidase, and total antioxidant capacity serum levels. The optimal extraction process was determined using various ingredients to obtain complex extracts with high active ingredient content and antioxidant activity. DPPH assay results showed that the optimized ingredients have antioxidant effects, and the combination had better antioxidation function than YPS in vitro. The combination also showed synergistic antioxidant activity compared with YPS in vivo. CONCLUSIONS: The combination of YPS and FSI had a synergistic antioxidant effect in vitro. The optimized extracts had antioxidant effects in vivo. These results indicated that YPS could be used with FSI to improve its antioxidant capacity in the body on the basis of free radical scavenging capacity.
has issue date	2020-05-18(xsd:dateTime)
bibo:doi	10.1016/j.biopha.2020.110265
bibo:pmid	32425327
has license	no-cc
sha1sum (hex)	43612112b10a9fbb3227b082f6623a4365cc1694
schema:url	https://doi.org/10.1016/j.biopha.2020.110265
resource representing a document's title	Evaluation of the synergetic effect of Yupingfeng san and Flos Sophorae Immaturus based on free radical scavenging capacity
has PubMed Central identifier	PMC7233259
has PubMed identifier	32425327
schema:publication	Biomed Pharmacother
resource representing a document's body	covid:43612112b10a9fbb3227b082f6623a4365cc1694#body_text
is schema:about of	named entity 'Pharmacotherapy' named entity 'doi' named entity 'synergetic' named entity 'Evaluation' named entity 'ABSTRACT' named entity 'MYP' named entity 'DOI' covid:arg/43612112b10a9fbb3227b082f6623a4365cc1694 named entity 'doi' named entity 'equally' named entity 'elasticity' named entity 'Chinese medicine' named entity 'YPS' named entity 'TCM' named entity 'free radicals' named entity 'centrifuged' named entity 'free radicals' named entity 'free radical' named entity 'https' named entity 'Evaluation' named entity 'free radical scavenging' named entity 'polysaccharides' named entity 'antioxidant effect' named entity 'synergistic' named entity 'free radical scavenging' named entity 'assay' named entity 'synergetic effect' named entity 'FSI' named entity 'phenol' named entity 'H2O2' named entity 'raw material' named entity 'protect against ultraviolet' named entity 'free radicals' named entity 'supernatant' named entity 'raw material' named entity 'synergistic effect' named entity 'active ingredients' named entity 'influenza virus' named entity 'antioxidant' named entity 'carbohydrate' named entity 'Laboratory animal' named entity 'pneumonia' named entity '2019-nCoV' named entity 'synergistic effect' named entity 'superoxide anion' named entity 'antioxidant activities' named entity 'polysaccharide' named entity 'hypertension' named entity 'statistically significant' named entity 'raw material' named entity 'chi-square test' named entity 'anions' named entity 'CAT' named entity 'flavonoid' named entity 'enzyme' named entity 'standard deviation' named entity 'sediment' named entity 'flavonoid' named entity 'antioxidant' named entity 'scavenging activity' named entity 'anti-oxidant' named entity 'flavonoid' named entity 'reactive nitrogen' named entity 'synergistic' named entity 'scavenge' named entity 'Leguminosae'

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