About: A hidden gene in astroviruses encodes a viroporin

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About: A hidden gene in astroviruses encodes a viroporin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A hidden gene in astroviruses encodes a viroporin
Creator	Lulla, Valeria Firth, Andrew
Source	Medline; PMC
abstract	Human astroviruses are small non-enveloped viruses with positive-sense single-stranded RNA genomes. Astroviruses cause acute gastroenteritis in children worldwide and have been associated with encephalitis and meningitis in immunocompromised individuals. It is still unknown how astrovirus particles exit infected cells following replication. Through comparative genomic analysis and ribosome profiling we here identify and confirm the expression of a conserved alternative-frame ORF, encoding the protein XP. XP-knockout astroviruses are attenuated and pseudo-revert on passaging. Further investigation into the function of XP revealed plasma and trans Golgi network membrane-associated roles in virus assembly and/or release through a viroporin-like activity. XP-knockout replicons have only a minor replication defect, demonstrating the role of XP at late stages of infection. The discovery of XP advances our knowledge of these important human viruses and opens an additional direction of research into their life cycle and pathogenesis.
has issue date	2020-08-13(xsd:dateTime)
bibo:doi	10.1038/s41467-020-17906-x
bibo:pmid	32792502
has license	cc-by
sha1sum (hex)	4366db3bd13255f3cb83115303a2eb0df3d90c47
schema:url	https://doi.org/10.1038/s41467-020-17906-x
resource representing a document's title	A hidden gene in astroviruses encodes a viroporin
has PubMed Central identifier	PMC7426862
has PubMed identifier	32792502
schema:publication	Nat Commun
resource representing a document's body	covid:4366db3bd13255f3cb83115303a2eb0df3d90c47#body_text
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