About: Saliva as a Candidate for COVID-19 Diagnostic Testing: A Meta-Analysis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Saliva as a Candidate for COVID-19 Diagnostic Testing: A Meta-Analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Saliva as a Candidate for COVID-19 Diagnostic Testing: A Meta-Analysis
Creator	Czumbel, László Farkas, Nelli Gábor Varga, Hegyi, Anita Hegyi, Péter Kiss, Szabolcs Lohinai, Zsolt Mandel, Iván Nagy, Ákos Steward, Martin Szakács, Zsolt Varga, Gábor
source	MedRxiv
abstract	Objectives: Our aim was to conduct a meta-analysis on the reliability and consistency of SARS-CoV-2 viral RNA detection in saliva specimens. Methods: We reported our meta-analysis according to the Cochrane Handbook. We searched the Cochrane Library, Embase, Pubmed, Scopus, Web of Science and clinical trial registries for eligible studies published between 1 January and 25 April 2020. The number of positive tests and total number of conducted tests were collected as raw data. The proportion of positive tests in the pooled data were calculated by score confidence interval estimation with the Freeman-Tukey transformation. Heterogeneity was assessed using the I2 measure and the Chi2 test. Results: The systematic search revealed 96 records after removal of duplicates. 26 records were included for qualitative analysis and 5 records for quantitative synthesis. We found 91% (95%CI = 80%-99%) sensitivity for saliva tests and 98% (95%CI 89%-100%) sensitivity for nasopharyngeal swab (NPS) tests in previously confirmed COVID-19 infected patients, with moderate heterogeneity among studies. Additionally, we identified 18 registered, ongoing clinical trials on saliva-based tests for detection of the virus. Conclusion: Saliva tests offer a promising alternative to NPS for COVID-19 diagnosis. However, further diagnostic accuracy studies are needed to improve their specificity and sensitivity.
has issue date	2020-05-27(xsd:dateTime)
bibo:doi	10.1101/2020.05.26.20112565
has license	medrxiv
sha1sum (hex)	436eba972b937a9a8478024aa3c9f78371a696bb
schema:url	https://doi.org/10.1101/2020.05.26.20112565
resource representing a document's title	Saliva as a Candidate for COVID-19 Diagnostic Testing: A Meta-Analysis
resource representing a document's body	covid:436eba972b937a9a8478024aa3c9f78371a696bb#body_text
is schema:about of	named entity 'OBJECTIVES' covid:arg/436eba972b937a9a8478024aa3c9f78371a696bb named entity 'meta-analysis' named entity 'Saliva' named entity 'COVID-19' named entity 'preprint' named entity 'infection' named entity 'confounding factors' named entity 'preprint' named entity 'Case reports' named entity 'confidence intervals' named entity 'SARS-CoV-2' named entity 'Open Science Framework' named entity 'peer review' named entity 'specificity and sensitivity' named entity 'viral RNA' named entity 'subgroup analyses' named entity 'oral cavity' named entity 'diagnostic test' named entity 'April 2020' named entity 'virus' named entity 'meta-analysis' named entity 'COVID-19' named entity 'saliva' named entity 'human DNA' named entity 'medRxiv' named entity 'Vijayakumar' named entity 'case series' named entity 'EUA' named entity 'preprint' named entity 'SARS' named entity 'nasopharyngeal swab' named entity 'virus' named entity 'COVID-19' named entity 'saliva' named entity 'Nasopharyngeal swab' named entity 'peer review' named entity 'saliva tests' named entity 'medRxiv' named entity 'statistical analysis' named entity 'rhesus macaques' named entity 'preprint' named entity 'Carcano' named entity 'COVID-19' named entity 'saliva' named entity 'meta-analysis study' named entity 'saliva tests' named entity 'SARS' named entity 'sensitivity and specificity' named entity 'preprint' named entity 'database' named entity 'preprint' named entity 'saliva tests' named entity 'RNA extraction' named entity 'clinical trial' named entity 'saliva' named entity 'risk ratio' named entity 'saliva' named entity 'clinical studies' named entity 'selective reporting' named entity 'COVID-19' named entity 'Meta-Analyses' named entity 'preprint' named entity 'peer review' named entity 'saliva' named entity 'saliva' named entity 'viruses' named entity 'SARS-CoV-2' named entity 'coronavirus' named entity 'saliva tests' named entity 'COVID-19' named entity 'Cochrane Library' named entity 'nasopharyngeal swab' named entity 'case report'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software