About: CORONAVIRUS REVERSE GENETIC SYSTEMS: INFECTIOUS CLONES AND REPLICONS

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	CORONAVIRUS REVERSE GENETIC SYSTEMS: INFECTIOUS CLONES AND REPLICONS
Creator	Enjuanes, Luis Sola, Isabel Almazán, Fernando Marquez-Jurado, Silvia Zuñiga, Sonia Becares, Martina Morales, Lucia
source	Elsevier; Medline; PMC
abstract	Coronaviruses (CoVs) infect humans and many animal species, and are associated with respiratory, enteric, hepatic, and central nervous system diseases. The large size of the CoV genome and the instability of some CoV replicase gene sequences during its propagation in bacteria, represent serious obstacles for the development of reverse genetic systems similar to those used for smaller positive sense RNA viruses. To overcome these limitations, several alternatives to more conventional plasmid-based approaches have been established in the last thirteen years. In this report, we briefly review and discuss the different reverse genetic systems developed for CoVs, paying special attention to the severe acute respiratory syndrome CoV (SARS-CoV).
has issue date	2014-08-01(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2014.05.026
bibo:pmid	24930446
has license	bronze-oa
sha1sum (hex)	43d195717d02e34be24cc80d371079fd9c346338
schema:url	https://doi.org/10.1016/j.virusres.2014.05.026
resource representing a document's title	CORONAVIRUS REVERSE GENETIC SYSTEMS: INFECTIOUS CLONES AND REPLICONS
has PubMed Central identifier	PMC4727449
has PubMed identifier	24930446
schema:publication	Virus Research
resource representing a document's body	covid:43d195717d02e34be24cc80d371079fd9c346338#body_text
is schema:about of	named entity 'genetic' named entity 'GENETIC' named entity 'SEQUENCES' named entity 'SIZE' named entity 'ASSOCIATED WITH' named entity 'GENE' named entity 'COVS' named entity 'OVERCOME' named entity 'HAVE' named entity 'DEVELOPMENT' named entity 'DIFFERENT' named entity 'HEPATIC' named entity 'BASED' named entity 'REPRESENT' named entity 'BACTERIA' named entity 'DISCUSS' named entity 'CONVENTIONAL' named entity 'ITS' named entity 'LARGE' named entity 'YEARS' named entity 'REVERSE' named entity 'ANIMAL SPECIES' named entity 'CENTRAL NERVOUS SYSTEM DISEASES' named entity 'HUMANS' named entity 'APPROACHES' named entity 'PROPAGATION' named entity 'CORONAVIRUSES' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'CLONES' named entity 'REVERSE' named entity 'REPORT' named entity 'THESE' named entity 'ENTERIC' named entity 'LIMITATIONS' named entity 'PLASMID' named entity 'SYSTEMS' named entity 'RNA VIRUSES' named entity 'ATTENTION' named entity 'INSTABILITY' named entity 'SYSTEMS' named entity 'CORONAVIRUS' named entity 'SENSE' named entity 'POSITIVE' named entity 'INFECT' named entity 'USED' named entity 'SMALLER' named entity 'GENETIC' named entity 'REVIEW' named entity 'SPECIAL' named entity 'SIMILAR' named entity 'GENOME' named entity 'REPLICASE' named entity 'RESPIRATORY' named entity 'INFECTIOUS' named entity 'ESTABLISHED' named entity 'genome' named entity 'alternatives' named entity 'paying' named entity 'large' named entity 'systems' named entity 'Coronaviruses' named entity 'gene sequences' named entity 'central nervous system diseases' named entity 'hepatic' named entity 'bacteria' named entity 'reverse genetic' named entity 'reverse genetic' named entity 'animal species' named entity 'genome' named entity 'CoV' named entity 'replicons' named entity 'development' named entity 'BSL3' named entity 'replicon' named entity 'virus'

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