About: Intrahost selection pressures drive rapid dengue virus microevolution in acute human infections

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About: Intrahost selection pressures drive rapid dengue virus microevolution in acute human infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Intrahost selection pressures drive rapid dengue virus microevolution in acute human infections
Creator	Harris, Eva Balmaseda, Angel Wang, Chunling Correspondence, Balmaseda, Eva Eswarappa, Magelda Eswarappa, Meghana Montoya, Angel Montoya, Magelda Parameswaran, Poornima Surbhi, Bharat Trivedi, Meghana Trivedi, Surbhi
source	Elsevier; Medline; PMC
abstract	Dengue, caused by four dengue virus serotypes (DENV-1–DENV-4), is a highly-prevalent mosquito-borne viral disease in humans. Yet, selection pressures driving DENV microevolution within human hosts (‘intrahost’) remain unknown. We employed a whole-genome segmented amplification approach coupled with deep sequencing to profile DENV-3 intrahost diversity in peripheral blood mononuclear cell (PBMC) and plasma samples from 77 dengue patients. DENV-3 intrahost diversity appears to be driven by immune pressures as well as replicative success in PBMCs and potentially other replication sites. Hotspots for intrahost variation were detected in 59–78% of patients in the viral Envelope and pre-Membrane/Membrane proteins, which together form the virion surface. Dominant variants at the hotspots arose via convergent microevolution, appear to be immune-escape variants, and were evolutionarily constrained at the macro-level due to viral replication defects. Dengue is thus an example of an acute infection in which selection pressures within infected individuals drive rapid intrahost virus microevolution.
has issue date	2017-09-01(xsd:dateTime)
bibo:doi	10.1016/j.chom.2017.08.003
bibo:pmid	28910637
has license	hybrid-oa
sha1sum (hex)	43e785aa37376f5531f66729ae83fcc9955145ab
schema:url	https://doi.org/10.1016/j.chom.2017.08.003
resource representing a document's title	Intrahost selection pressures drive rapid dengue virus microevolution in acute human infections
has PubMed Central identifier	PMC5616187
has PubMed identifier	28910637
schema:publication	Cell Host & Microbe
resource representing a document's body	covid:43e785aa37376f5531f66729ae83fcc9955145ab#body_text
is schema:about of	named entity 'PRESSURES' named entity 'CONSTRAINED' named entity 'SITES' named entity 'PRESSURE' named entity 'SUMMARY' named entity 'RAPID' named entity 'MICROEVOLUTION' named entity 'DENGUE VIRUS' named entity 'SELECTION' named entity 'INFECTIONS' named entity 'ARTICLE' named entity 'DRIVE' named entity 'DENV-3' named entity 'DENGUE' named entity 'LIKELY' named entity 'DIVERSITY' named entity 'PATIENTS' named entity 'IMMUNE' named entity 'VIRUS' named entity 'ESCAPE' named entity 'VARIANTS' named entity 'HOTSPOT' named entity 'REPLICATION' named entity 'INCLUDING' named entity 'PBMCS' named entity 'PLASMA' named entity 'MICROEVOLUTION' named entity 'SHAPED' named entity 'HUMAN' named entity 'ACUTE' named entity 'ANALYZED' covid:arg/43e785aa37376f5531f66729ae83fcc9955145ab named entity 'PBMCs' named entity 'microevolution' named entity 'microevolution' named entity 'microevolution' named entity 'Selection Pressures' named entity 'Microevolution' named entity 'D.J.' named entity 'chimpanzee' named entity 'dengue' named entity 'high-throughput sequencing' named entity 'DENV' named entity 'antibody-mediated immunity' named entity 'mosquito' named entity 'histidine' named entity 'reverse transcription' named entity 'evolutionary mechanisms' named entity 'PCR' named entity 'locus' named entity 'gender identity' named entity 'drug resistance' named entity 'virus' named entity 'plasma' named entity 'DSS' named entity 'PBMC' named entity 'Qiagen' named entity 'loci' named entity 'high-throughput sequencing' named entity 'Fisher's exact test' named entity 'DHF' named entity 'loci' named entity 'lung' named entity 'Fastq' named entity 'coding region' named entity '1, 2' named entity 'primers' named entity 'Fisher's exact test' named entity 'vaccine'

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