About: Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir

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About: Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir
Creator	Perera, Rushika Gullberg, Rebekah Meyerson, Nicholas Sawyer, Sara Gilchrist, Alison Old, William Stabell, Alex Webb, Kristofor
Source	PMC
abstract	Human dengue viruses emerged from primate reservoirs, yet paradoxically dengue does not reach high titers in primate models. This presents a unique opportunity to examine the genetics of spillover versus reservoir hosts. The dengue virus 2 (DENV2) - encoded protease cleaves human STING, reducing type I interferon production and boosting viral titers in humans. We find that both human and sylvatic (reservoir) dengue viruses universally cleave human STING, but not the STING of primates implicated as reservoir species. The special ability of dengue to cleave STING is thus specific to humans and a few closely related ape species. Conversion of residues 78/79 to the human-encoded ‘RG’ renders all primate (and mouse) STINGs sensitive to viral cleavage. Dengue viruses may have evolved to increase viral titers in the dense and vast human population, while maintaining decreased titers and pathogenicity in the more rare animals that serve as their sustaining reservoir in nature.
has issue date	2018-03-20(xsd:dateTime)
bibo:doi	10.7554/elife.31919
bibo:pmid	29557779
has license	cc-by
sha1sum (hex)	43f0fd3b0c765c0dc92a49d8ac4a50a75a0135b7
schema:url	https://doi.org/10.7554/elife.31919
resource representing a document's title	Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir
has PubMed Central identifier	PMC5860865
has PubMed identifier	29557779
resource representing a document's body	covid:43f0fd3b0c765c0dc92a49d8ac4a50a75a0135b7#body_text
is schema:about of	named entity 'PRESUMED' named entity 'dengue' named entity 'This' named entity 'STING' named entity 'production' named entity 'mouse' named entity 'humans' named entity 'Dengue' named entity 'REDUCING' named entity 'DENGUE VIRUSES' named entity 'ENCODED' named entity 'CONVERSION' named entity 'STING' named entity 'GENETICS' named entity 'SPECIFIC' named entity 'HUMAN' named entity 'BOOSTING' named entity 'BUT' named entity 'EVOLVED' named entity 'DENGUE' named entity 'APE' named entity 'ABILITY' named entity 'SPECIES' named entity 'PATHOGENICITY' named entity 'SYLVATIC' named entity 'HIGH' named entity 'RARE' named entity 'RELATED' named entity 'DOES NOT REACH' named entity 'NATURE' named entity 'HUMAN POPULATION' named entity 'OPPORTUNITY' named entity 'DENGUE VIRUS 2' named entity 'PRESENTS' named entity 'SENSITIVE TO' named entity 'MOUSE' named entity 'UNIQUE' named entity 'RESERVOIRS' named entity 'MAINTAINING' named entity 'PRIMATE' named entity 'TO INCREASE' named entity 'NONHUMAN PRIMATES' named entity 'ANIMALS' named entity 'THEIR' named entity 'RESERVOIR' named entity 'NATURAL' named entity 'HUMANS' named entity 'STING' named entity 'DENGUE VIRUSES' named entity 'SUSTAINING' named entity 'TO CLEAVE' named entity 'TO EXAMINE' named entity 'DECREASED' named entity 'THEIR' named entity 'HUMANS' named entity 'HOSTS' named entity 'PROTEASE' named entity 'SPILLOVER' named entity 'CLEAVES' named entity 'CLEAVAGE' named entity 'MAY HAVE' named entity 'SERVE' named entity 'DENSE' named entity 'BUT' named entity 'PRIMATES' named entity 'MODELS' named entity 'VIRAL' named entity 'RESERVOIR' named entity 'SPECIAL' named entity 'TYPE I INTERFERON PRODUCTION' covid:arg/43f0fd3b0c765c0dc92a49d8ac4a50a75a0135b7 named entity 'special' named entity 'cleave' named entity 'STING' named entity 'protease'

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