About: Multicenter Evaluation of BioFire FilmArray Respiratory Panel 2 for Detection of Viruses and Bacteria in Nasopharyngeal Swab Samples

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multicenter Evaluation of BioFire FilmArray Respiratory Panel 2 for Detection of Viruses and Bacteria in Nasopharyngeal Swab Samples
Creator	Daly, Judy Leber, Amy Everhart, Kathy Harrington, Amanda Holmberg, Kristen Hopper, Aubrey Jones, Matthew Kensinger, Bart Schreckenberger, Paul Mckinley, Kathleen
Source	Medline; PMC
abstract	The FilmArray Respiratory Panel 2 (RP2) is a multiplex in vitro diagnostic test for the simultaneous and rapid (∼45-min) detection of 22 pathogens directly from nasopharyngeal swab (NPS) samples. It contains updated (and in some instances redesigned) assays that improve upon the FilmArray Respiratory Panel (RP; version 1.7), with a faster run time. The organisms identified are adenovirus, coronavirus 229E, coronavirus HKU1, coronavirus NL63, coronavirus OC43, human metapneumovirus, human rhinovirus/enterovirus, influenza virus A, influenza virus A H1, influenza virus A H1-2009, influenza virus A H3, influenza virus B, parainfluenza virus 1, parainfluenza virus 2, parainfluenza virus 3, parainfluenza virus 4, respiratory syncytial virus, Bordetella pertussis, Chlamydia pneumoniae, and Mycoplasma pneumoniae. Two new targets are included in the FilmArray RP2: Middle East respiratory syndrome coronavirus and Bordetella parapertussis. This study provides data from a multicenter evaluation of 1,612 prospectively collected NPS samples, with performance compared to that of the FilmArray RP or PCR and sequencing. The overall percent agreement between the FilmArray RP2 and the comparator testing was 99.2%. The RP2 demonstrated a positive percent agreement of 91.7% or greater for detection of all but three analytes: coronavirus OC43, B. parapertussis, and B. pertussis. The FilmArray RP2 also demonstrated a negative percent agreement of ≥93.8% for all analytes. Of note, the adenovirus assay detects all genotypes, with a demonstrated increase in sensitivity. The FilmArray RP2 represents a significant improvement over the FilmArray RP, with a substantially shorter run time that could aid in the diagnosis of respiratory infections in a variety of clinical scenarios.
has issue date	2018-05-25(xsd:dateTime)
bibo:doi	10.1128/jcm.01945-17
bibo:pmid	29593057
has license	cc-by
sha1sum (hex)	44001ef9803c7765b699fd7a95eb1edac878c840
schema:url	https://doi.org/10.1128/jcm.01945-17
resource representing a document's title	Multicenter Evaluation of BioFire FilmArray Respiratory Panel 2 for Detection of Viruses and Bacteria in Nasopharyngeal Swab Samples
has PubMed Central identifier	PMC5971546
has PubMed identifier	29593057
schema:publication	J Clin Microbiol
resource representing a document's body	covid:44001ef9803c7765b699fd7a95eb1edac878c840#body_text
is schema:about of	named entity 'pathogens' named entity 'Mycoplasma pneumoniae' named entity 'Viruses' named entity 'PANEL' named entity 'IS A' named entity 'DIAGNOSTIC TEST' named entity 'ADENOVIRUS' named entity 'DETECTION' named entity 'SIMULTANEOUS' named entity 'INFLUENZA VIRUS A H1' named entity 'VERSION' named entity 'PARAINFLUENZA VIRUS 4' named entity 'CORONAVIRUS NL63' named entity 'CHLAMYDIA PNEUMONIAE' named entity 'INFLUENZA VIRUS A' named entity 'ORGANISMS' named entity 'CORONAVIRUS OC43' named entity 'DETECTION' named entity 'NASOPHARYNGEAL SWAB' named entity 'PARAINFLUENZA VIRUS 2' named entity '1.7' named entity 'IN VITRO' named entity 'PARAINFLUENZA VIRUS 1' named entity 'CONTAINS' named entity 'CORONAVIRUS HKU1' named entity 'MYCOPLASMA PNEUMONIAE' named entity 'PARAINFLUENZA VIRUS 3' named entity 'UPDATED' covid:arg/44001ef9803c7765b699fd7a95eb1edac878c840 named entity 'IDENTIFIED' named entity 'RESPIRATORY' named entity 'PATHOGENS' named entity 'BACTERIA ' named entity 'VIRUSES' named entity 'INFLUENZA VIRUS B' named entity 'BORDETELLA PERTUSSIS' named entity 'INFLUENZA VIRUS A H3' named entity 'DIRECTLY' named entity 'MULTIPLEX' named entity 'MIN' named entity 'RESPIRATORY' named entity 'SAMPLES' named entity 'NASOPHARYNGEAL SWAB' named entity 'PANEL' named entity 'RAPID' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'HUMAN RHINOVIRUS' named entity 'FASTER' named entity 'TIME' named entity 'EVALUATION' named entity 'SAMPLES' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'VITRO DIAGNOSTIC' named entity 'CORONAVIRUS 229E' named entity 'RUN' named entity '2009' named entity 'coronavirus' named entity 'Chlamydia pneumoniae' named entity 'detection' named entity 'enterovirus' named entity 'coronavirus' named entity 'parainfluenza virus' named entity 'parainfluenza virus' named entity 'nasopharyngeal swab' named entity 'coronavirus' named entity 'parainfluenza virus' named entity 'adenovirus' named entity 'coronavirus' named entity 'influenza virus' named entity 'OC43' named entity 'NL63' named entity 'GenBank'

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