About: Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors

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About: Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors
Creator	Liang, Po-Huang Tan, Kian-Pin Kumar, Vathan Lin, Sheng-Wei Wang, Ying-Ming
Source	Elsevier; Medline; PMC
abstract	Severe acute respiratory syndrome (SARS) led to a life-threatening form of atypical pneumonia in late 2002. Following that, Middle East Respiratory Syndrome (MERS-CoV) has recently emerged, killing about 36% of patients infected globally, mainly in Saudi Arabia and South Korea. Based on a scaffold we reported for inhibiting neuraminidase (NA), we synthesized the analogues and identified compounds with low micromolar inhibitory activity against 3CL(pro) of SARS-CoV and MERS-CoV. Docking studies show that a carboxylate present at either R(1) or R(4) destabilizes the oxyanion hole in the 3CL(pro). Interestingly, 3f, 3g and 3m could inhibit both NA and 3CL(pro) and serve as a starting point to develop broad-spectrum antiviral agents.
has issue date	2016-07-01(xsd:dateTime)
bibo:doi	10.1016/j.bmc.2016.05.013
bibo:pmid	27240464
has license	no-cc
sha1sum (hex)	440505bd6ffa90117eeaddd0b4d31f0020715233
schema:url	https://doi.org/10.1016/j.bmc.2016.05.013
resource representing a document's title	Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors
has PubMed Central identifier	PMC7079562
has PubMed identifier	27240464
schema:publication	Bioorg Med Chem
resource representing a document's body	covid:440505bd6ffa90117eeaddd0b4d31f0020715233#body_text
is schema:about of	covid:arg/440505bd6ffa90117eeaddd0b4d31f0020715233 named entity 'studies' named entity 'Severe acute respiratory syndrome (SARS)' named entity 'protein' named entity 'Chromatographic purification' named entity 'micromolar' named entity 'antiviral agents' named entity 'analogues' named entity 'Saudi Arabia' named entity 'SARS' named entity 'neuraminidase' named entity 'SARS-CoV' named entity 'Middle East Respiratory Syndrome' named entity '3C-like protease' named entity 'peptide' named entity 'pharmacophores' named entity 'MERS-CoV' named entity 'coxsackievirus' named entity 'phenyl group' named entity 'hydrazines' named entity 'pyrazolone' named entity 'acetic acid' named entity 'oxyanion hole' named entity 'alkyl' named entity 'viral particle' named entity 'hydrophobic' named entity 'rational design' named entity 'SARS' named entity 'Taiwan' named entity 'genus' named entity 'SARS' named entity 'Carbon' named entity 'inoculate' named entity 'methoxy group' named entity 'proteolysis' named entity 'parts per million' named entity 'phenylhydrazine' named entity 'Gln' named entity 'structurally similar' named entity 'ampicillin' named entity 'pyrazolone' named entity 'hydrophobic' named entity 'reaction mixture' named entity 'South Korea' named entity 'lysis buffer' named entity 'benzoic acid' named entity 'active sites' named entity 'hydrophobic' named entity '5.8' named entity 'moiety' named entity 'SARS-CoV' named entity 'DTT' named entity '2.2' named entity 'MERS-CoV' named entity 'salt' named entity 'tautomerism' named entity 'electron' named entity 'high throughput screening' named entity 'Equimolar' named entity 'MERS-CoV' named entity 'rhinovirus' named entity 'protease' named entity 'SARS-CoV' named entity 'H-bond' named entity 'MERS' named entity 'Phe' named entity 'significant difference' named entity '2.2' named entity 'MERS-CoV' named entity 'tautomer' named entity 'active site' named entity '7.5' named entity 'electron' named entity 'drug repurposing' named entity 'substrate binding' named entity 'moiety' named entity 'moiety'

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