About: The Supramap project: linking pathogen genomes with geography to fight emergent infectious diseases

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About: The Supramap project: linking pathogen genomes with geography to fight emergent infectious diseases Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Supramap project: linking pathogen genomes with geography to fight emergent infectious diseases
Creator	Janies, Daniel Alexandrov, Boyan Chen, Jennifer Ferreira, Renato Habib, Farhat Treseder, Travis Wheeler, Ward Varo´n, Andre´s
Source	Medline; PMC
abstract	Novel pathogens have the potential to become critical issues of national security, public health and economic welfare. As demonstrated by the response to Severe Acute Respiratory Syndrome (SARS) and influenza, genomic sequencing has become an important method for diagnosing agents of infectious disease. Despite the value of genomic sequences in characterizing novel pathogens, raw data on their own do not provide the information needed by public health officials and researchers. One must integrate knowledge of the genomes of pathogens with host biology and geography to understand the etiology of epidemics. To these ends, we have created an application called Supramap (http://supramap.osu.edu) to put information on the spread of pathogens and key mutations across time, space and various hosts into a geographic information system (GIS). To build this application, we created a web service for integrated sequence alignment and phylogenetic analysis as well as methods to describe the tree, mutations, and host shifts in Keyhole Markup Language (KML). We apply the application to 239 sequences of the polymerase basic 2 (PB2) gene of recent isolates of avian influenza (H5N1). We map a mutation, glutamic acid to lysine at position 627 in the PB2 protein (E627K), in H5N1 influenza that allows for increased replication of the virus in mammals. We use a statistical test to support the hypothesis of a correlation of E627K mutations with avian‐mammalian host shifts but reject the hypothesis that lineages with E627K are moving westward. Data, instructions for use, and visualizations are included as supplemental materials at: http://supramap.osu.edu/sm/supramap/publications. © The Willi Hennig Society 2010.
has issue date	2011-01-04(xsd:dateTime)
bibo:doi	10.1111/j.1096-0031.2010.00314.x
bibo:pmid	32313364
has license	no-cc
sha1sum (hex)	44970b3883429431bcec3d70c78b5f9ac5171eae
schema:url	https://doi.org/10.1111/j.1096-0031.2010.00314.x
resource representing a document's title	The Supramap project: linking pathogen genomes with geography to fight emergent infectious diseases
has PubMed Central identifier	PMC7162175
has PubMed identifier	32313364
schema:publication	Cladistics
resource representing a document's body	covid:44970b3883429431bcec3d70c78b5f9ac5171eae#body_text
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