About: Process Analytical Technologies and Data Analytics for the Manufacture of Monoclonal Antibodies

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Process Analytical Technologies and Data Analytics for the Manufacture of Monoclonal Antibodies
Creator	Ardekani, Arezoo Ladisch, Michael Maruthamuthu, Murali Rudge, Scott Verma, Mohit
source	Elsevier; Medline; PMC
abstract	Process analytical technology (PAT) for the manufacture of monoclonal antibodies (mAbs) is defined by an integrated set of advanced and automated methods that analyze the compositions and biophysical properties of cell culture fluids, cell-free product streams, and biotherapeutic molecules that are ultimately formulated into concentrated products. In-line or near-line probes and systems are remarkably well developed, although challenges remain in the determination of the absence of viral loads, detecting microbial or mycoplasma contamination, and applying data-driven deep learning to process monitoring and soft sensors. In this review, we address the current status of PAT for both batch and continuous processing steps and discuss its potential impact on facilitating the continuous manufacture of biotherapeutics.
has issue date	2020-08-21(xsd:dateTime)
bibo:doi	10.1016/j.tibtech.2020.07.004
bibo:pmid	32839030
has license	no-cc
sha1sum (hex)	44c9785b001d4b4b987c7bad86f076667c30ea7e
schema:url	https://doi.org/10.1016/j.tibtech.2020.07.004
resource representing a document's title	Process Analytical Technologies and Data Analytics for the Manufacture of Monoclonal Antibodies
has PubMed Central identifier	PMC7442002
has PubMed identifier	32839030
schema:publication	Trends Biotechnol
resource representing a document's body	covid:44c9785b001d4b4b987c7bad86f076667c30ea7e#body_text
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