About: Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay

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About: Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay
Creator	Vandesompele, Jo Ciuffi, Angela De Bleser, Pieter De Spiegelaere, Ward Lefever, Steve Mestdagh, Pieter Mohammadi, Pejman Saeys, Yvan Trypsteen, Wim Van Hecke, Clarissa Vandekerckhove, Linos Ghent, Belgium
source	PMC
abstract	Studying the effects of HIV infection on the host transcriptome has typically focused on protein-coding genes. However, recent advances in the field of RNA sequencing revealed that long non-coding RNAs (lncRNAs) add an extensive additional layer to the cell’s molecular network. Here, we performed transcriptome profiling throughout a primary HIV infection in vitro to investigate lncRNA expression at the different HIV replication cycle processes (reverse transcription, integration and particle production). Subsequently, guilt-by-association, transcription factor and co-expression analysis were performed to infer biological roles for the lncRNAs identified in the HIV-host interplay. Many lncRNAs were suggested to play a role in mechanisms relying on proteasomal and ubiquitination pathways, apoptosis, DNA damage responses and cell cycle regulation. Through transcription factor binding analysis, we found that lncRNAs display a distinct transcriptional regulation profile as compared to protein coding mRNAs, suggesting that mRNAs and lncRNAs are independently modulated. In addition, we identified five differentially expressed lncRNA-mRNA pairs with mRNA involvement in HIV pathogenesis with possible cis regulatory lncRNAs that control nearby mRNA expression and function. Altogether, the present study demonstrates that lncRNAs add a new dimension to the HIV-host interplay and should be further investigated as they may represent targets for controlling HIV replication.
has issue date	2016-10-26(xsd:dateTime)
bibo:doi	10.1038/srep36111
bibo:pmid	27782208
has license	cc-by
sha1sum (hex)	44cbdded77107e8c97330deef77b1b761a9bb229
schema:url	https://doi.org/10.1038/srep36111
resource representing a document's title	Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay
has PubMed Central identifier	PMC5080576
has PubMed identifier	27782208
schema:publication	Sci Rep
resource representing a document's body	covid:44cbdded77107e8c97330deef77b1b761a9bb229#body_text
is schema:about of	named entity 'RNA' named entity 'production' named entity 'add' named entity 'additional' named entity 'mRNA' named entity 'processes' named entity 'OPEN' named entity 'HIV' named entity 'FUNCTION' named entity 'PROCESSES' named entity 'ROLES' named entity 'TRANSCRIPTIONAL REGULATION' named entity 'IN VITRO' named entity 'THE CELL' named entity 'BIOLOGICAL' named entity 'GENES' named entity 'LAYER' named entity 'DIFFERENTIAL EXPRESSION' named entity 'NEW' named entity 'ADDITION' named entity 'PROFILE' named entity 'TRANSCRIPTION FACTOR' named entity 'EXTENSIVE' named entity 'RESPONSES' named entity 'INVOLVEMENT' covid:arg/44cbdded77107e8c97330deef77b1b761a9bb229 named entity 'EXPRESSED' named entity 'INTEGRATION' named entity 'REVEALED' named entity 'TARGETS' named entity 'GUILT' named entity 'REGULATORY' named entity 'NEARBY' named entity 'HIV' named entity 'INVESTIGATED' named entity 'CO-EXPRESSION ANALYSIS' named entity 'PRESENT' named entity 'EXPRESSION' named entity 'INFER' named entity 'PROTEIN-CODING' named entity 'ASSOCIATION' named entity 'HOST' named entity 'CELL CYCLE REGULATION' named entity 'RECENT' named entity 'COMPARED' named entity 'CODING' named entity 'DISTINCT' named entity 'DISPLAY' named entity 'PARTICLE' named entity 'MRNA EXPRESSION' named entity 'NETWORK' named entity 'PATHWAYS' named entity 'PATHOGENESIS' named entity 'TRANSCRIPTION FACTOR BINDING' named entity 'HERE' named entity 'DIMENSION' named entity 'HIV' named entity 'ADDITIONAL' named entity 'PLAY' named entity 'REPRESENT' named entity 'PERFORMED' named entity 'IN THE FIELD' named entity 'MECHANISMS' named entity 'BINDING ANALYSIS' named entity 'UBIQUITINATION' named entity 'PRIMARY HIV INFECTION' named entity 'MODULATED' named entity 'ROLE' named entity 'DIFFERENT' named entity 'HIV INFECTION'

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