About: Porcine Epidemic Diarrhea Virus and the Host Innate Immune Response

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine Epidemic Diarrhea Virus and the Host Innate Immune Response
Creator	Zheng, Haixue Zhu, Zixiang Li, Shasha Yang, Jinping
Source	Medline; PMC
abstract	Porcine epidemic diarrhea virus (PEDV), a swine enteropathogenic coronavirus (CoV), is the causative agent of porcine epidemic diarrhea (PED). PED causes lethal watery diarrhea in piglets, which has led to substantial economic losses in many countries and is a great threat to the global swine industry. Interferons (IFNs) are major cytokines involved in host innate immune defense, which induce the expression of a broad range of antiviral effectors that help host to control and antagonize viral infections. PEDV infection does not elicit a robust IFN response, and some of the mechanisms used by the virus to counteract the host innate immune response have been unraveled. PEDV evades the host innate immune response by two main strategies including: 1) encoding IFN antagonists to disrupt innate immune pathway, and 2) hiding its viral RNA to avoid the exposure of viral RNA to immune sensors. This review highlights the immune evasion mechanisms employed by PEDV, which provides insights for the better understanding of PEDV-host interactions and developing effective vaccines and antivirals against CoVs.
has issue date	2020-05-11(xsd:dateTime)
bibo:doi	10.3390/pathogens9050367
bibo:pmid	32403318
has license	cc-by
sha1sum (hex)	44d82c80fe0fd8a8913964f74cdc7f0299da21dc
schema:url	https://doi.org/10.3390/pathogens9050367
resource representing a document's title	Porcine Epidemic Diarrhea Virus and the Host Innate Immune Response
has PubMed Central identifier	PMC7281546
has PubMed identifier	32403318
schema:publication	Pathogens
resource representing a document's body	covid:44d82c80fe0fd8a8913964f74cdc7f0299da21dc#body_text
is schema:about of	named entity 'effectors' named entity 'avoid' named entity 'great' named entity 'epidemic' named entity 'insights' named entity 'PED' named entity 'encoding' named entity 'EXPOSURE' named entity 'LETHAL' named entity 'VACCINES' named entity 'MECHANISMS' named entity 'VIRAL RNA' covid:arg/44d82c80fe0fd8a8913964f74cdc7f0299da21dc named entity 'swine' named entity 'involved' named entity 'porcine' named entity 'substantial' named entity 'RNA' named entity 'host' named entity 'sensors' named entity 'developing' named entity 'host' named entity 'control' named entity 'causative agent' named entity 'Interferons' named entity 'diarrhea' named entity 'PEDV' named entity 'infection' named entity 'mechanisms' named entity 'ISGF3' named entity 'HCoV-229E' named entity 'MHV' named entity 'caspase-2' named entity 'PAMPs' named entity 'caspase-3' named entity 'virus' named entity 'epitopes' named entity 'Sendai virus' named entity 'infection' named entity 'IKKε' named entity 'TYK2' named entity '32, 36' named entity 'PKR' named entity 'intestinal epithelial cells' named entity 'TRIM25' named entity 'type I IFN' named entity 'viral RNA' named entity 'innate immune responses' named entity 'IFN' named entity 'protein kinase' named entity 'CBP' named entity 'protein expression' named entity 'nsp4' named entity 'PEDV' named entity 'exoribonuclease' named entity 'ubiquitinated' named entity 'NF-κB' named entity 'PEDV' named entity 'Ubiquitination' named entity 'methylation' named entity 'membrane-bound' named entity 'RNA viruses' named entity 'PEDV' named entity 'PEDV' named entity 'S-phase' named entity 'interleukin-8' named entity 'virus' named entity 'viral RNA' named entity 'nsp6' named entity 'viral RNA replication' named entity 'infection' named entity 'IFN' named entity 'receptor subunits' named entity 'sequence alignment' named entity 'genome' named entity 'cytokines' named entity 'infection' named entity 'stress response'

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