About: Catatonia and the immune system: a review

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About: Catatonia and the immune system: a review Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Catatonia and the immune system: a review
Creator	Blackman, Graham David, Anthony Pollak, Thomas Rogers, Jonathan
Source	Elsevier; Medline; PMC
abstract	Catatonia is a psychomotor disorder featuring stupor, posturing, and echophenomena. This Series paper examines the evidence for immune dysregulation in catatonia. Activation of the innate immune system is associated with mutism, withdrawal, and psychomotor retardation, which constitute the neurovegetative features of catatonia. Evidence is sparse and conflicting for acute-phase activation in catatonia, and whether this feature is secondary to immobility is unclear. Various viral, bacterial, and parasitic infections have been associated with catatonia, but it is primarily linked to CNS infections. The most common cause of autoimmune catatonia is N-methyl-D-aspartate receptor (NMDAR) encephalitis, which can account for the full spectrum of catatonic features. Autoimmunity appears to cause catatonia less by systemic inflammation than by the downstream effects of specific actions on extracellular antigens. The specific association with NMDAR encephalitis supports a hypothesis of glutamatergic hypofunction in catatonia.
has issue date	2019-06-10(xsd:dateTime)
bibo:doi	10.1016/s2215-0366(19)30190-7
bibo:pmid	31196793
has license	no-cc
sha1sum (hex)	44e7f0291b99258a00ce08264de9d0af7511f2b4
schema:url	https://doi.org/10.1016/s2215-0366%2819%2930190-7
resource representing a document's title	Catatonia and the immune system: a review
has PubMed Central identifier	PMC7185541
has PubMed identifier	31196793
schema:publication	Lancet Psychiatry
resource representing a document's body	covid:44e7f0291b99258a00ce08264de9d0af7511f2b4#body_text
is schema:about of	named entity 'encephalitis' named entity 'Autoimmunity' named entity 'ASSOCIATED WITH' named entity 'UNCLEAR' named entity 'AUTOIMMUNE' named entity 'FEATURE' named entity 'ASSOCIATION' named entity 'MUTISM' named entity 'PARASITIC' named entity 'SPECIFIC' named entity 'PHASE' named entity 'IMMUNE SYSTEM' named entity 'VARIOUS' named entity 'IMMUNE DYSREGULATION' named entity 'EXTRACELLULAR' named entity 'HYPOTHESIS' named entity 'AUTOIMMUNITY' named entity 'ENCEPHALITIS' named entity 'ANTIGENS' named entity 'IS A' named entity 'EVIDENCE' named entity 'ACUTE' named entity 'CATATONIA' named entity 'PSYCHOMOTOR DISORDER' named entity 'CONFLICTING' named entity 'EFFECTS' named entity 'IMMOBILITY' named entity 'CNS INFECTIONS' named entity 'NMDAR' named entity 'CAUSE' named entity 'ACTIONS' named entity 'SPARSE' named entity 'POSTURING' named entity 'HYPOFUNCTION' named entity 'COMMON' named entity 'FEATURES' named entity 'VIRAL' named entity 'N-METHYL-D-ASPARTATE RECEPTOR' named entity 'GLUTAMATERGIC' named entity 'PSYCHOMOTOR RETARDATION' named entity 'ACTIVATION' named entity 'CATATONIA' named entity 'BUT' named entity 'WITHDRAWAL' named entity 'INFECTIONS' named entity 'BACTERIAL' named entity 'ACCOUNT' named entity 'EVIDENCE FOR' named entity 'HAVE' named entity 'DOWNSTREAM' named entity 'CATATONIC' named entity 'STUPOR' named entity 'PAPER' named entity 'FULL SPECTRUM' named entity 'SECONDARY TO' named entity 'SYSTEMIC INFLAMMATION' named entity 'INNATE IMMUNE SYSTEM' named entity 'SERIES' named entity 'REVIEW' covid:arg/44e7f0291b99258a00ce08264de9d0af7511f2b4 named entity 'catatonia' named entity 'viral' named entity 'features' named entity 'paper' named entity 'catatonia' named entity 'NMDAR' named entity 'autoimmune' named entity 'parasitic infections' named entity 'catatonia' named entity 'catatonia' named entity 'NMDAR' named entity 'systemic inflammation' named entity 'encephalitis' named entity 'antigens' named entity 'glutamatergic' named entity 'Catatonia' named entity 'mutism' named entity 'zygotes'

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