About: Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2
Creator	Zhang, Jing Li, Lin Li, Wendong Fan, Yubo He, Yufei Sun, Ting
Source	BioRxiv; MedRxiv
abstract	The outbreak of the 2019 novel coronavirus (SARS-CoV-2) has infected thousands of people with a large number of deaths across 26 countries. The sudden appearance of the virus leads to the limited existing therapies for SARS-CoV-2. Therefore, vaccines and antiviral medicines are in desperate need. This study took immune-informatics approaches to identify B- and T-cell epitopes for surface glycoprotein (S) of SARS-CoV-2, followed by estimating their antigenicity and interactions with the human leukocyte antigen (HLA) alleles. We identified four B cell epitopes, two MHC class-I and nine MHC class-II binding T-cell epitopes, which showed highly antigenic features. Allergenicity, toxicity and physiochemical properties analysis confirmed the specificity and selectivity of epitopes. The stability and safety of epitopes were confirmed by digestion analysis. No mutations were observed in all the selected B- and T-cell epitopes across all isolates from different locations worldwide. Epitopes were thus identified and some of them can be potential candidates for vaccine development.
has issue date	2020-02-27(xsd:dateTime)
bibo:doi	10.1101/2020.02.25.965434
has license	biorxiv
sha1sum (hex)	451b48e918674b51899d2afc438849da973ad062
schema:url	https://doi.org/10.1101/2020.02.25.965434
resource representing a document's title	Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2
schema:publication	bioRxiv
resource representing a document's body	covid:451b48e918674b51899d2afc438849da973ad062#body_text
is schema:about of	named entity 'SARS-CoV-2' named entity 'epitopes' named entity 'worldwide' named entity 'coronavirus' named entity 'disease' named entity 'EPITOPES' named entity 'LEADS' named entity 'MEDICINES' named entity 'SPECIFICITY' named entity 'selectivity' named entity 'development' named entity 'Therefore' named entity 'coronavirus' named entity 'epitopes' named entity 'safety' named entity 'highly' named entity 'This' named entity 'human leukocyte antigen (HLA)' named entity 'vaccines' named entity 'caused' named entity 'antigenic' named entity 'alleles' named entity 'vaccines' named entity 'epitopes' named entity 'HLA' named entity 'epitopes' named entity 'coronavirus' named entity 'antiviral' named entity 'epitopes' named entity 'epitopes' named entity 'Allergenicity' named entity 'Epitopes' named entity 'SARS-CoV-2' named entity 'T-cell' named entity 'antigenicity' named entity 'spike (S) protein' named entity 'peptides' named entity 'vaccines' named entity 'SVM' named entity 'class I fusion protein' named entity 'B-cell' named entity 'beta turn' named entity 'epitopes' named entity 'peptide' named entity 'B-cell' named entity 'FOLD3' named entity 'toxin' named entity 'protein' named entity 'binding affinity' named entity 'biotechnology' named entity 'allele' named entity 'epitopes' named entity 'antigenicity' named entity 'peptide' named entity 'HLA' named entity 'epitopes' named entity 'epitope' named entity 'T-lymphocyte' named entity '2.0' named entity 'receptor' named entity 'antiviral drugs' named entity 'half-life' named entity 'epitopes' named entity 'NCBI' named entity 'epitopes' named entity 'HLA' named entity 'vaccine' named entity 'MHC class II' named entity 'B-cell' named entity 'January 30' named entity 'HLA-B35' named entity 'epitopes' named entity 'hydrophilicity' named entity 'protein' named entity 'T-cell' named entity 'protein' named entity 'peptides' named entity 'lung infections' named entity 'protein'

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