About: Implications of Obesity for the Management of Severe Coronavirus Disease 2019 Pneumonia

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Implications of Obesity for the Management of Severe Coronavirus Disease 2019 Pneumonia
Creator	Komorowski, Matthieu Arumadura, Clothilde Courageux, Nathan Granier, Maxime Lemyze, Malcolm Maladobry, Thomas Mallat, Jihad Orfi, Annis Pauquet, Philippe
topic	covid:45a1d1c248dfc118d60d8c59709ac0246cc8b2c4#this
Source	Medline; PMC
abstract	To investigate patients’ characteristics, management, and outcomes in the critically ill population admitted to the ICU for severe acute respiratory syndrome coronavirus disease 2019 pneumonia causing an acute respiratory distress syndrome. DESIGN: Retrospective case-control study. SETTING: A 34-bed ICU of a tertiary hospital. PATIENTS: The first 44 coronavirus disease 2019 acute respiratory distress syndrome patients were compared with a historical control group of 39 consecutive acute respiratory distress syndrome patients admitted to the ICU just before the coronavirus disease 2019 crisis. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Obesity was the most frequent comorbidity exhibited by coronavirus disease 2019 patients (n = 32, 73% vs n = 11, 28% in controls; p < 0.001). Despite the same severity of illness and level of hypoxemia at admission, coronavirus disease 2019 patients failed more high flow oxygen via nasal cannula challenges (n = 16, 100% vs n = 5, 45% in controls; p = 0.002), were more often intubated (n = 44, 100% vs n = 22, 56% in controls; p < 0.001) and paralyzed (n = 34, 77% vs n = 3, 14% in controls; p < 0.001), required higher level of positive end-expiratory pressure (15 vs 8 cm H(2)O in controls; p < 0.001), more prone positioning (n = 33, 75% vs n = 6, 27% in controls; p < 0.001), more dialysis (n = 16, 36% vs n = 3, 8% in controls; p = 0.003), more hemodynamic support by vasopressors (n = 36, 82% vs n = 22, 56% in controls; p = 0.001), and had more often a prolonged weaning from mechanical ventilation (n = 28, 64% vs n = 10, 26% in controls; p < 0.01) resulting in a more frequent resort to tracheostomy (n = 18, 40.9% vs n = 2, 9% in controls; p = 0.01). However, an intensive management requiring more staff per patient for positioning coronavirus disease 2019 subjects (6 [5–7] vs 5 [4–5] in controls; p < 0.001) yielded the same ICU survival rate in the two groups (n = 34, 77% vs n = 29, 74% in controls; p = 0.23). CONCLUSIONS: In its most severe form, coronavirus disease 2019 pneumonia striked preferentially the vulnerable obese population, evolved toward a multiple organ failure, required prolonged mechanical ventilatory support, and resulted in a high workload for the caregivers.
has issue date	2020-05-26(xsd:dateTime)
bibo:doi	10.1097/ccm.0000000000004455
bibo:pmid	32452889
has license	no-cc
sha1sum (hex)	45a1d1c248dfc118d60d8c59709ac0246cc8b2c4
schema:url	https://doi.org/10.1097/ccm.0000000000004455
resource representing a document's title	Implications of Obesity for the Management of Severe Coronavirus Disease 2019 Pneumonia
has PubMed Central identifier	PMC7255399
has PubMed identifier	32452889
schema:publication	Crit Care Med
resource representing a document's body	covid:45a1d1c248dfc118d60d8c59709ac0246cc8b2c4#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/45a1d1c248dfc118d60d8c59709ac0246cc8b2c4
is schema:about of	named entity 'workload' named entity 'patient' named entity 'evolved' named entity 'weaning' named entity 'Despite' named entity 'ICU' named entity 'Care' named entity 'VENTILATORY SUPPORT' named entity 'SURVIVAL RATE' named entity 'POSITIVE END-EXPIRATORY PRESSURE' named entity 'STAFF' named entity 'TRACHEOSTOMY' named entity 'HIGH FLOW' named entity 'CAREGIVERS' covid:arg/45a1d1c248dfc118d60d8c59709ac0246cc8b2c4 named entity 'nasal cannula' named entity 'Setting' named entity 'Measurements' named entity 'acute respiratory distress syndrome' named entity 'controls' named entity 'Med' named entity 'controls' named entity 'ICU' named entity 'patients' named entity 'ARDS' named entity 'pneumonia' named entity 'SAPS II' named entity 'ground-glass opacities' named entity 'controls' named entity 'hypoxemia' named entity 'pneumonia' named entity 'Objectives' named entity 'Interventions' named entity 'controls' named entity 'ICU' named entity 'coronavirus disease 2019' named entity 'comorbidity' named entity 'multiple organ failure' named entity 'pneumonia' named entity 'acute respiratory distress syndrome' named entity 'obese' named entity 'pneumonia' named entity 'critically ill' named entity 'acute respiratory distress syndrome' named entity 'coronavirus disease 2019' named entity '0.01' named entity 'patients' named entity 'ICU' named entity 'ARDS' named entity 'COVID' named entity 'Armonk' named entity 'lung' named entity 'PEEP' named entity 'tracheostomy' named entity 'obesity' named entity 'COVID' named entity 'respiratory failure' named entity 'thorax' named entity 'comorbidities' named entity 'ARDS' named entity 'massively obese' named entity 'type 1' named entity 'COVID' named entity 'diaphragm' named entity 'COVID-19' named entity 'tracheostomy' named entity 'critically ill patients' named entity 'lungs' named entity 'COVID-19' named entity 'ARDS' named entity 'Berlin'

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