About: A Prospective Cohort Study of Factors Associated with Empiric Antibiotic De-escalation in Neonates Suspected with Early Onset Sepsis (EOS)

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: A Prospective Cohort Study of Factors Associated with Empiric Antibiotic De-escalation in Neonates Suspected with Early Onset Sepsis (EOS) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A Prospective Cohort Study of Factors Associated with Empiric Antibiotic De-escalation in Neonates Suspected with Early Onset Sepsis (EOS)
Creator	Zaini, Mohd Ain, Nazedah Ain, Nurul Bakry, Makmor Mohd, · Noraida, · Rashidah, Nur Shah, Mohamed Tahir, Mohd
source	PMC
abstract	BACKGROUND: Prolonged empiric antibiotic use, resulting from diagnostic uncertainties, in suspected early onset sepsis (EOS) cases constitutes a significant problem. Unnecessary antibiotic use increases the risk of antibiotic resistance. Furthermore, prolonged antibiotic use increases the risk of mortality and morbidity in neonates. Proactive measures including empiric antibiotic de-escalation are crucial to overcome these problems. METHODS: This was a prospective cohort study conducted in the neonatal intensive care units of two public hospitals in Malaysia. Neonates with a gestational age greater than 34 weeks who were started on empiric antibiotics within 72 h of life were screened. The data were then stratified according to de-escalation and non-de-escalation practices, where de-escalation practice was defined as narrowing down or discontinuation of empiric antibiotic within 72 h of treatment. RESULTS: A total of 1045 neonates were screened, and 429 were included. The neonates were then divided based on de-escalation (n = 207) and non-de-escalation (n = 222) practices. Neonates under non-de-escalation practices showed significantly longer durations of antibiotic use compared to those under de-escalation practices (p < 0.05), with no difference in treatment outcomes. Five factors were found to be associated with de-escalation of antibiotics. They are cesarean section delivery, exposure to antenatal steroids, nil history of maternal pyrexia, absence of meconium-stained amniotic fluid, and normal C-reactive protein ≤ 0.5 mg/dL (p < 0.05). CONCLUSIONS: Empiric antibiotic de-escalation appears feasible as a routine form of treatment for EOS in late preterm and term neonates.
has issue date	2020-03-18(xsd:dateTime)
bibo:doi	10.1007/s40272-020-00388-1
bibo:pmid	32185682
has license	no-cc
sha1sum (hex)	4658cfca9c88c99e3184308c241854ffa479ca0e
schema:url	https://doi.org/10.1007/s40272-020-00388-1
resource representing a document's title	A Prospective Cohort Study of Factors Associated with Empiric Antibiotic De-escalation in Neonates Suspected with Early Onset Sepsis (EOS)
has PubMed Central identifier	PMC7222079
has PubMed identifier	32185682
schema:publication	Paediatr Drugs
resource representing a document's body	covid:4658cfca9c88c99e3184308c241854ffa479ca0e#body_text
is schema:about of	named entity 'neonatal intensive care units' named entity 'neonates' named entity 'cesarean' named entity 'morbidity' named entity 'sepsis' named entity 'antibiotics' named entity 'de-escalation' named entity 'cases' named entity 'total' named entity 'Empiric' named entity 'antibiotic' named entity 'Onset' named entity 'ROUTINE' named entity 'overcome' named entity 'early' named entity 'problem' named entity 'demographic' named entity 'EOS' named entity 'blood culture' named entity 'de-escalation' named entity 'blood culture' named entity 'penicillin' named entity 'de-escalation' named entity 'antibiotic' named entity 'de-escalation' named entity 'PCR' named entity 'risk assessment' named entity 'empiric antibiotic' named entity 'empiric antibiotic' named entity 'pyrexia' named entity 'meconium' named entity 'meconium' named entity 'antibiotics' named entity 'chorioamnionitis' named entity 'EOS' named entity 'Neonates' named entity 'blood cultures' named entity 'EOS' named entity 'American College of Obstetricians and Gynecologists' named entity 'candidiasis' named entity 'cesarean section' named entity 'antibiotic' named entity 'first-line' named entity 'blood culture' named entity 'de-escalation' named entity 'antibiotics' named entity 'antibiotic prophylaxis' named entity 'EOS' named entity 'escalation rate' named entity 'gram positive' named entity 'polymerase chain reaction' named entity 'antibiotics' named entity 'antibiotics' named entity 'microbial' named entity 'blood culture' named entity 'gestation' named entity 'Estonia' named entity 'infection' named entity 'penicillin' named entity 'neonatal intensive care units' named entity 'ventilator-associated pneumonia' named entity 'pyrexia' named entity 'antibiotic' named entity 'blood cultures' named entity '28 days' named entity 'infection' named entity 'CRP' named entity 'Ministry of Health, Malaysia' named entity 'sepsis' named entity 'empiric antibiotic' named entity 'Ministry of Health, Malaysia' named entity 'antibiotics' named entity 'blood culture'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software