About: Transient plant production of Salmonella Typhimurium diagnostic antibodies

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Transient plant production of Salmonella Typhimurium diagnostic antibodies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Transient plant production of Salmonella Typhimurium diagnostic antibodies
Creator	Hust, Michael Freyer, Cornelia Kopertekh, Lilya Meyer, Torsten
source	PMC
abstract	Salmonella Typhimurium is one of the most important zoonotic pathogens worldwide and a major cause of economic losses in the pig production chain. The emergence of multi-drug resistant strains over the past years has led to considerations about an enhanced surveillance of bacterial food contamination. Currently, ELISA is the method of choice for high throughput identification of S. Typhimurium. The sensitivity and specificity of this assay might be improved by application of new diagnostic antibodies. We focused on plant-based expression of candidate diagnostic TM43-E10 antibodies discovered using as antigen the S. Typhimurium OmpD protein. The scFv-TM43-E10 and scFv-Fc-TM43-E10 antibody derivatives have been successfully produced in N. benthamiana using a deconstructed movement-deficient PVX vector supplemented with the γb silencing suppressor from Poa semilatent virus. The plant-made antibodies showed the same antigen-binding specificity as that of the microbial/mammalian cell-produced counterparts and could recognize the OmpD antigen in S. Typhimurium infected plant samples.
has issue date	2019-02-12(xsd:dateTime)
bibo:doi	10.1016/j.btre.2019.e00314
bibo:pmid	30847285
has license	cc-by-nc-nd
sha1sum (hex)	4707f1bde6c93904ce5481e8d38e86a3fc2cd36e
schema:url	https://doi.org/10.1016/j.btre.2019.e00314
resource representing a document's title	Transient plant production of Salmonella Typhimurium diagnostic antibodies
has PubMed Central identifier	PMC6389800
has PubMed identifier	30847285
schema:publication	Biotechnol Rep (Amst)
resource representing a document's body	covid:4707f1bde6c93904ce5481e8d38e86a3fc2cd36e#body_text
is schema:about of	named entity 'CHOICE' named entity 'DRUG RESISTANT' named entity 'ASSAY' named entity 'SALMONELLA TYPHIMURIUM' named entity 'LED' named entity 'CANDIDATE' named entity 'CURRENTLY' named entity 'PROTEIN' named entity 'BINDING SPECIFICITY' named entity 'CONSIDERATIONS' named entity 'MIGHT BE' named entity 'FOCUSED' named entity 'IDENTIFICATION' named entity 'ABOUT' named entity 'BACTERIAL' named entity 'NEW' named entity 'SILENCING' named entity 'MULTI' named entity 'EXPRESSION' named entity 'YEARS' named entity 'ONE OF' named entity 'CELL' named entity 'ECONOMIC' named entity 'economic' named entity 'antibodies' named entity 'Typhimurium' named entity 'sensitivity' named entity 'http' named entity 'PLANT PRODUCTION' named entity 'CAUSE' named entity 'SAMPLES' named entity 'TRANSIENT' named entity 'ELISA' named entity 'DIAGNOSTIC' named entity 'HAVE' named entity 'SALMONELLA TYPHIMURIUM' named entity 'NC-' named entity 'DIAGNOSTIC' named entity 'ANTIBODIES' named entity 'LICENSE' named entity 'PLANT' named entity 'IMPROVED BY' named entity 'APPLICATION' named entity 'ZOONOTIC PATHOGENS' named entity 'SENSITIVITY AND SPECIFICITY' named entity 'ANTIBODY' named entity 'CHAIN' named entity 'EMERGENCE' named entity 'POA SEMILATENT VIRUS' named entity 'WORLDWIDE' named entity 'PRODUCTION' named entity 'PVX' named entity 'FOOD CONTAMINATION' named entity 'STRAINS' named entity 'USING' named entity 'PLANT-' named entity 'ORG' named entity 'SURVEILLANCE' named entity 'OMPD' named entity 'INFECTED' named entity 'ANTIGEN' named entity 'E10' named entity 'SCFV' named entity 'MICROBIAL' named entity 'METHOD' named entity 'IN S' named entity 'SUPPRESSOR' named entity 'PIG' named entity 'RECOGNIZE' named entity 'BASED' named entity 'HIGH THROUGHPUT' named entity 'PAST' named entity 'A MAJOR' named entity 'VECTOR' named entity 'ENHANCED' named entity 'IMPORTANT' named entity 'ANTIBODIES' covid:arg/4707f1bde6c93904ce5481e8d38e86a3fc2cd36e

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software