About: Between-centre differences for COVID-19 ICU mortality from early data in England

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Between-centre differences for COVID-19 ICU mortality from early data in England
Creator	Ercole, Ari Alaa, Ahmed Qian, Zhaozhi Van Der Schaar, Mihaela
Source	MedRxiv
abstract	The high numbers of COVID-19 patients developing severe respiratory failure has placed exceptional demands on ICU capacity around the world. Understanding the determinants of ICU mortality is important for surge planning and shared decision making. We used early data from the COVID-19 Hospitalisation in England Surveillance System (from the start of data collection 8th February -14th April 2020) to look for factors associated with ICU outcome in the hope that information from such timely analysis may be actionable before the outbreak peak. Immunosuppression, chronic renal disease and age were key determinants of ICU mortality in a proportional hazards mixed effects model. However variation in site-stratified random effects were even more appreciable, suggesting substantial between-centre variability in mortality. Notwithstanding possible ascertainment and lead-time effects, these early results motivate comparative effectiveness research to understand the origin of such differences and optimise surge ICU provision.
has issue date	2020-04-27(xsd:dateTime)
bibo:doi	10.1101/2020.04.19.20070722
has license	medrxiv
sha1sum (hex)	470ad44d0c57fd9c03c0a72dff180a95c2a783e0
schema:url	https://doi.org/10.1101/2020.04.19.20070722
resource representing a document's title	Between-centre differences for COVID-19 ICU mortality from early data in England
resource representing a document's body	covid:470ad44d0c57fd9c03c0a72dff180a95c2a783e0#body_text
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