About: Human rabies in China: evidence-based suggestions for improved case detection and data gathering

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About: Human rabies in China: evidence-based suggestions for improved case detection and data gathering Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human rabies in China: evidence-based suggestions for improved case detection and data gathering
Creator	Feng, Yun Li, Hao Yu, Peng-Cheng Liu, Jia-Jia Cai, Liang Ding, Shu-Jun Liu, Shu-Qing Lu, Xue-Xin Tao, Xiao-Yan Zhu, Wu-Yang
Source	PMC
abstract	BACKGROUND: China still suffers heavily from rabies, although reported human cases continue to decrease year over year. There are far fewer laboratory-confirmed human cases than clinically diagnosed cases, which is a big problem that needs to be addressed. In this report, we summarize analyses of all specimens from human cases tested in our laboratory over the past 15 years, in order to promote laboratory diagnosis of rabies. METHODS: From 2005 to 2019, a total of 271 samples from 164 suspected rabies cases were collected from local hospitals by the local Centers for Disease Control and Prevention (CDCs) in China. Saliva, cerebrospinal fluid (CSF), serum (blood) and urine were collected for ante-mortem diagnosis, and brain tissue, neck skin tissue and cornea were collected for post-mortem diagnosis. All of the specimens were tested by reverse transcription-polymerase chain reaction (RT-PCR), and brain tissues were also tested using fluorescent antibody test (FAT). The number of positive test results obtained using different fluids or tissues, and at different stages of the disease, were compared using a chi-square test and a more effective sampling program is recommended. RESULTS: As the national reference laboratory for rabies surveillance in China, our laboratory has tested 271 samples from 164 suspected rabies cases collected by local CDCs since 2005. We found that saliva gave the highest number of positive test results (32%), compared with CSF and other fluids. We also found that serum or blood specimens collected in the last 3 days of life can test positive by RT-PCR. CONCLUSIONS: Serum or blood samples collected in the last 3 days of a patient’s life can be used to measure viral RNA, which means that serum samples, as well as saliva and CSF, can be used to detect viral RNA for anti-mortem diagnosis of rabies. Because of our findings, we have modified our “National Surveillance Project for Human Rabies”, by adding the collection and testing of serum samples from the end of the survival period. This will improve our national surveillance and laboratory diagnosis of human rabies.
has issue date	2020-06-01(xsd:dateTime)
bibo:doi	10.1186/s40249-020-00672-9
has license	cc-by
sha1sum (hex)	472efc330f8826f01214117925fc0c39194478e4
schema:url	https://doi.org/10.1186/s40249-020-00672-9
resource representing a document's title	Human rabies in China: evidence-based suggestions for improved case detection and data gathering
has PubMed Central identifier	PMC7266119
schema:publication	Infect Dis Poverty
resource representing a document's body	covid:472efc330f8826f01214117925fc0c39194478e4#body_text
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